K.L. Cantagallo; M.M. Jericó; R. Lucas; R.T. Rolan
Granulomatous sebaceous adenitis is an idiopathic primary inflammatory disorder of the sebaceous glands. Although many breeds may be affected, there is a high incidence in standard poodles, vizsla, akitas and Samoyeds. The severity of clinical signs varies according to the breed and haircoat type. Differential diagnosis included folliculitis, demodicidosis, dermatophytosis, defects in keratinization (seborrhea and Ichthyosis), follicular dysplasia, endocrinopathies seborrhea, dermatosis responsive to vitamin A, demodicidosis and follicular dysplasia. The present resume describes the clinical and histopathological findings of a 6 years old Akita male dog presented at the Veterinary Teaching Hospital of Anhembi Morumbi University with moderate itching, peeling and oil aspect of the skin for 1 year long. The skin was characterized by alopecic, erythematosus, symmetrical, desquamative and progressive dermatosis. The macroscopic evaluation showed areas of alopecia with scaling, rarefaction, "plugs" of hair keratin adhered to, and pustules in the abdominal region, skin showing the skin sparingly and irregularly thickened by acanthosis with granular and horny layers thick noting also in the stratum corneum outbreaks of parakeratosis. In the papillary dermis there are slight interstitial edema and dilation of blood vessels with mild interstitial infiltrate lymphomononuclear. The infundibulum and isthmus follicular are extended by keratin. Of reticular dermis were not observed in sebaceous glands seriate cuts made, and the apocrine gland secretion of dilated and sometimes surrounded by lymphomononuclear infiltrate. There is also thickening of the collagen fibers around the hair follicles. The previously performed skin biopsy revealed sebaceous adenitis. Treatment was started with topical cyclosporine. Two milliliters of cyclosporine (Sandimun® Neoral oral solution, 100 mg/ml) were diluted in 100 ml of oil. The mixture was topically applied and rinsed twice a week. After 4 month, further improvement was noted and new hair regrowth was apparent.