Antagonistic Effects of Flumazenil on Tiletamine-Zolazepam Induced Anesthesia in Dogs
World Small Animal Veterinary Association World Congress Proceedings, 2009
M.C. Kim1; H.S. Won1; J.Y. Lee1; S.M. Jeong1; C.S. Park2
1Department of Veterinary Surgery, College of Veterinary Medicine, Research Institute of Veterinary Medicine and 2Division of Animal Science & Resources, Research Center for Transgenic Cloned Pigs, Chungnam National University, Daejeon, Korea

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To determine the antagonistic effects of flumazenil on anesthesia induced in dogs with tiletamine/zolazepam (TZ).


There was a crossover experimental design in 6 healthy dogs. Initially, 10 mg/kg of TZ was injected into the cephalic vein of 6 dogs (TZ group). After a 2 week break, TZ was administered and 20 minutes later, the dogs were given 0.1 mg/kg flumazenil, a benzodiazepine antagonist (TZF group). This study examined the scores of anesthetic effects, recovery times, vital signs and blood biochemistry of the two groups in 7 time categories (pre-anesthesia, 1, 5, 20, 40, 60, 90 minutes after anesthesia).


The flumazenil showed a excellent antagonist effect in analgesia, posture, and auditory response. However, it did not have antagonistic effect on sedation and muscle relaxation. The TZF group had a higher mean heart rate at 20 and 30 minutes than the TZ group. The TZF group had a significantly higher mean temperature at 5, 20, 30 and 60 minutes than the TZ group. After the administration of flumazenil, the glucose level of TZF group was significantly higher than that of the TZ group (P < 0.05). The TP level in the TZ group decreased significantly from the baseline at 5, 20 and 30 minutes. On the other hand, the TP level in the TZF group decreased significantly from baseline at 5 minutes (P < 0.05). The AST of TZ group was increased significantly from the baseline at 1 minute but it remained within the normal range. While recovering from anesthesia, the times for head up, sternal recumbency, standing and walking after recovery from anesthesia in the TZ group were 29.7±9.5, 50.7±19.9, 82.0±23.6 and 96.2±28.0 respectively. The respective values in the TZF group were 32.8±14.4, 44.7±9.7, 66.2±20.1 and 74.5±25.0.


An injection of flumazenil after administering TZ shortened the recovery time from anesthesia. It caused changes in the vital signs and blood biochemistry but within the normal range. Flumazenil has a property to have antagonistic effect on TZ without side effect.

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M.C. Kim
Department of Veterinary Surgery
College of Veterinary Medicine
Chungnam National University, Daejeon, Korea

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