Evaluation of Oxidant/Antioxidant Status in Dogs with Multicentric Lymphoma
ACVIM 2008
S.R.R. Lucas; M.G. Gimeno; C.M. Satsuki; V.A.B.F. Wirthl
School of Veterinary Medicine and Animal Science-University of São Paulo

Oxidative stress is an imbalance between oxidant and antioxidant defense mechanisms in favor of the oxidants, leading to cellular damage. Under normal circumstances, oxidants serve a protective function by killing bacteria and tumor cells. However, they can have detrimental side effects and DNA oxidative damage can contribute to aging, mutagenesis and carcinogenesis. Lymphomas comprise one of the most common groups of tumors in dogs and can be used as a model for this disease in humans. Cancer patients are reported to have generalized oxidative stress and oxidative damage within tumor tissues. The aim of this study was to evaluate the oxidant and antioxidant status in dogs with multicentric lymphoma. Serum samples were obtained from 15 dogs with multicentric lymphoma, stage III to V, at the diagnosis, without previous treatment and 20 healthy dogs (control group). Oxidative status was measured by the analysis of thiobarbituric acid reactive substances (TBARS) expressed as malondialdehyde (MDA). Total antioxidant status was measured by the use of a Randox TAS kit NX2332. Mean of MDA concentration was significantly higher in dogs with multicentric lymphoma at the diagnosis (2.96 µmol/L) than in healthy dogs (1.49 µmol/L). There was no difference in the total antioxidant status between the groups (0.965 and 0.957 mmol/L respectively).

In conclusion dogs with multicentric lymphoma showed increase in the levels of oxidative substances but the antioxidant defense mechanisms seem to be deteriorated. Studies are necessary to confirm if this finding may contribute to prognosis and response to the treatment.

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Sílvia Regina Ricci Lucas

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