Association Between Feline Pancreatic Lipase Immunoreactivity Concentration and the Presence of Serum Antibodies Against Toxoplasma gondii and Bartonella Spp
Feline pancreatitis is commonly diagnosed; however the cause is frequently unknown. It is possible that some cases may be caused by Toxoplasma gondii or Bartonella spp. infection. Feline pancreatic lipase immunoreactivity (fPLI) is a non-invasive test for pancreatitis. The purpose of this study was to examine the association between fPLI concentration and T. gondii or Bartonella spp. antibodies in serum from cats.
Serum samples from 464 cats in which fPLI concentrations had been determined were assayed for T. gondii IgG, T. gondii IgM, and Bartonella spp. IgG using ELISA. Logistic regression analysis was used to evaluate the relationship between fPLI concentration and T. gondii or Bartonella spp. antibodies, with fPLI considered as both a binomial and continuous variable.
Of 179 (38.6%) cats with a serum fPLI concentration suggestive of pancreatitis (> 12 µg/L), 15 (8.4%), 13 (7.3%), and 34 (19%) were seropositive for T. gondii IgG, T. gondii IgM, or Bartonella spp. IgG, respectively. Of 285 cats with a serum fPLI concentration < 12 µg/L, 19 (6.7%), 20 (7.0%), and 54 (18.9%) were seropositive for T. gondii IgG, T. gondii IgM, or Bartonella spp. IgG, respectively. Cats with fPLI > 12 µg/L were no more likely to be seropositive for T. gondii or Bartonella spp. than cats with fPLI < 12 µg/L (P>0.05). Additionally, the correlation between fPLI concentration and T. gondii or Bartonella spp antibodies was not significant (P>0.05).
These results suggest that serological tests for these organisms may not be useful in all cases of feline pancreatitis.