Effects of Sucralfate on the Serum Phosphorus Concentration and Urinary Fractional Excretion of Phosphorus in Healthy Cats
Sucralfate is currently used as a gastric protectant in cats, but may also have phosphate binding activity. In humans, this can be a deleterious side-effect of administration, occasionally leading to hypophosphatemia. The purpose of this study was to determine the effect of sucralfate administration on the serum and urine phosphorus concentrations of healthy cats.
Six healthy 1.5 year old cats of mixed sex were used. Each cat was administered 500 mg of sucralfate orally as a slurry in 1.5 milliliters of water, three times daily before food for 14 consecutive days. Blood and urine samples were collected 3 days during the week prior to sucralfate administration (samples 1-3), 6 days during the 2 weeks of sucralfate administration (samples 4-9) and 2 days during the week post-administration (samples 10 and 11). Concentrations of phosphorus, calcium, potassium, sodium and creatinine were measured on all serum and urine samples. Fractional excretions of phosphorus, calcium, potassium and sodium in urine were calculated.
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No significant difference in serum phosphorus concentration or urinary excretion of phosphorus was seen between the treatment and non-treatment samples. Vomiting was noted as a side-effect 5 times out of 34 administrations.
We conclude that sucralfate does not cause hypophosphatemia in healthy cats at the administered dose.