Neurohormonal Measurements in Healthy Dogs and Dogs with Acquired Valvular or Myocardial Disease
ACVIM 2008
D.D. Sisson1; B.J. Bulmer1; P.F. Solter2; R.R. Panico1; R. Prošek3; M.A. Oyama4; D.F. Hogan5
1Oregon State University, Corvallis, OR, USA; 2University of Illinois, Urbana, IL, USA; 3Homstead, FL, USA; 4University of Pennsylvania, Philadelphia, PA, USA; 5Purdue University, West Lafayette, IN, USA

Alterations in circulating concentrations of neurohormones have been well characterized in humans with heart disease and heart failure but have been only partially characterized in dogs. To further characterize neuroendocrine changes, blood was collected by jugular venipuncture from dogs with congestive heart failure due to dilated cardiomyopathy (CHF-DCM, N=30) or degenerative valvular disease (CHF-DVD, N= 44); dogs with DCM but without CHF (E-DCM, N=30); dogs with DVD but without CHF (E-DVD, N = 45); and from 81 healthy dogs (Controls).

Dogs were evaluated via physical exam, ECG, thoracic radiographs, and echocardiography. Plasma renin activity (PRA), and serum aldosterone (ALDO), NT-proANP (ANP), and BNP were measured by RIA. Epinephrine (EPI) and norepinephrine (NOREPI) were measured by HPLC. Log-transformed data was analyzed via one-way ANOVA and using Bonferroni's multiple comparison tests with significance at P<0.05*. Results are reported as geometric means, (medians) and with [95%CI].

 

Controls

E-DVD

E-DCM

CHF-DVD

CHF-DCM

ANP
nmol/ml

0.47 (0.47)
[0.42-0.52]

0.95 (0.92)*
[0.76-1.18]

0.68 (0.72)
[0.53-0.87]

1.81 (1.75) *
[1.47-2.22]

1.26 (1.40) *
[1.00-1.58]

BNP
pg/ml

6.1 (9.0)
[4.6-8.0]

11.0 (13.3)
[6.8-17.8]

16.9 (16.3) *
[9.1-31.6]

15.4 (20.2) *
[9.5-24.8]

24.6 (25.1) *
[17.4-34.8]

PRA
ng/ml/hr

0.65 (0.80)
[0.50-0.83]

0.91 (0.95)
[0.67-1.24]

1.13 (0.90)
[0.81-1.59]

2.98 (3.41) *
[1.72-5.15]

6.01 (7.90) *
[3.80-9.50]

ALDO
pg/ml

34 (39)
[25.8-44.0]

49 (63)
[30.3-78.2]

80 (68)
[46.0-138.4]

66 (81) *
[42.9-100.9]

263 (214) *
[156-445]

EPI
pg/ml

133 (133)
[114-157]

290 (318) *
[232-364]

129 (126)
[93-178]

314 (302) *
[245-402]

211 (204) *
[166-267]

NOREPI
pg/ml

254 (263)
[220-291]

445 (416) *
[378-522]

276 (300)
[202-378]

574 (621) *
[461-715]

631 (625) *
[533-745]

NT-proANP, BNP, EPI, NOREPI, PRA and ALDO were increased in dogs with CHF due to DCM or DVD. NT-proANP, EPI and NOREPI were increased in dogs with DVD without CHF and BNP was increased in dogs with DCM without CHF.

Speaker Information
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David Sisson


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