Urine Protein Creatinine Ratio in Bernese Mountain Dogs of High or Low Risk of Developing Malignant Histiocytosis
ACVIM 2008
L. Nielsen; M. Aronsson; E. Persson; F. McEvoy; A. Lundorff Jensen; A.T. Kristensen
Department of Small Animal Clinical Studies, LIFE, University of Copenhagen
Denmark

Neoplastic conditions can result in proteinuria due to cancer related antigenic stimulation and subsequent glomerulonephropathy.

The aim of this study was to establish the normal urine protein creatinine ratio (UPC) in a population of healthy Bernese mountain dogs (BMD) and to assess if there was a difference in UPC in dogs of higher risk of developing malignant histiocytosis (MH) compared to dogs with a low risk of developing this neoplasia. Thirty-one healthy BMD aged 4-6 years, half of which came from families with a history of neoplasia, were screened for MH. The dogs were examined by blood work, urinalysis including culture and sensitivity, thoracic radiography and abdominal ultrasonography. The kidneys were examined specifically by UPC and by the resistance index. The UPC was performed by the enzymatic method.

Parameters were investigated using a multivariate analysis and linear correlations in SAS 9.0.

None of the dogs were diagnosed with renal disease or MH and there was no correlation between a family history of neoplasia and an elevated UPC. However most of the dogs had a UPC between 0.6 and 1 with the mean and standard deviation being 0.8-/+ 0.41, which is higher than that observed in published studies, including studies in other BMD.

The higher UPC could be explained by different methodology in the creatinine measurements or be due to slow progressive age related changes in the kidneys. Repeated UPC measurement in the same dogs to confirm proteinuria and further investigations of UPC in BMD affected by MH are warranted.

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Lise Nielsen


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