Post-Feeding Satiety and Weight Loss Effect of a Vegetable-Based Fiber Supplement in Beagles
Dietary insoluble fiber is believed to support weight loss by increasing satiety and allowing increased amounts of food consumption without adding calories, whereas dietary soluble fiber has potential to reduce cholesterol. Therefore, in this study, we evaluated a vegetable-based fiber supplement containing both soluble (SF) and insoluble fiber (IF) types on plasma lipid profiles, satiety, and weight loss in Beagles.
Two diets were fed differing in fiber content. Purina ONE® healthy weight formula (ONE) was compared to a diet consisting of ONE plus a vegetable-based fiber supplement (FIB). Total dietary fiber contents were 3.83g/100kcal (ONE) vs 6.89g/100kcal (FIB). The SF content of the FIB diet was 83.3% more than that of ONE (1.10g/100kcal vs 0.60g/100kcal in ONE) and IF content of the FIB diet was 79.6% more than that of ONE (5.80g/100kcal vs 3.23g/100kcal in ONE). For the satiety studies, female adult Beagles with average body fat (BF) of 37.5±1.4 (SEM) %, and body weight (BW) of 13.4±0.6 (SEM) kg were randomly divided into 2 diet groups. Diets were fed at 8am and 3pm (7h interval, n=14) or, during a second trial, at 8am and 11am (3h interval, n=12) for 15min each over a 3 or 2 day period, respectively. Amounts offered at each feeding were 1.2 times MER using a cross-over design with 3 days washout. Blood samples were collected after the 8am feeding at 45min and 120min and food intakes were recorded. For the weight loss study, 7 obese Beagles were selected (average BF 45.1±1.6%, BW 15.2±1.0kg, BCS 8.0±0.3 (9 point scale)) and divided into 2 groups. The diets were fed once daily (ca. 60% of obese MER) for 42 days. Postprandial blood samples were collected at 60min (days 1, 28 and 42) for lipid and lipoprotein analysis. Food intakes and BW were recorded daily and weekly, respectively. Repeated measures ANOVA was performed under α=0.05. Where there was significance, paired t or one-way AOV / Kruskal-Wallis tests with Tukey multiple comparisons were performed after checking normality.
In the satiety trials, both the 3 and 7h interval food intakes were not different from the control group indicating similar satiety of both diets. However, significantly fewer total calories were consumed with the FIB diet during the 3h interval study (p=0.017). Plasma triacylglycerol (TG) concentration was significantly increased at 120 min post feeding independent of diet compared to 45min (p<0.01). In the weight loss trial, the FIB group significantly reduced % BW (p=0.002) and % BF (p=0.008) over time. Plasma TG, total cholesterol (TC) and lipoprotein (LP) did not change. Thus, the increased percentage of IF in the FIB diet provided fewer calories with the same degree of satiety as the higher calorie intake of the control diet. In addition, this increase supported more efficient weight loss. However, the modestly increased amount of SF with the FIB diet did not affect plasma lipid profiles. In conclusion, the FIB diet appeared to provide similar satiety at lower calorie intake thereby promoting weight loss without modifying TG, TC and LP responses.