Relationship Between Prostatomegaly With or Without Mineralization and Cytologic Diagnosis in 55 Dogs
Prostatic neoplasia must be distinguished from other types of prostatic disease such as prostatitis, paraprostatic cysts, prostatic abscess and benign prostatic hypertrophy so as to direct therapy and allow prognostication. Mineralization has previously been associated with prostatic neoplasia in dogs. This studies purpose was to determine the connection between prostatic mineralization seen with imaging and cytologic assessment of the prostate in a large number of dogs.
Medical records of 55 dogs (22 neutered, 33 intact) with radiographic or ultrasonographic evidence of prostatomegaly and a cytologic diagnosis were retrospectively evaluated. Images were reviewed for mineralization and compared to results of fine needle aspiration (n=21), traumatic catheterization (n=2), biopsy (n=19) or necropsy (n=13).
Twenty-two out of fifty-five (40%) of dogs had prostatic neoplasia. Mineralization in neutered dogs had a positive predictive value (PPV) of 100%, negative predictive value (NPV) of 50%, sensitivity and specificity of 84% and 100% respectively. Mineralization in intact dogs had a PPV of 22%, NPV of 96%, and sensitivity and specificity of 67% and 77% respectively. All neutered dogs with prostatomegaly but not prostatic neoplasia had bacterial prostatitis and were castrated within the previous 3 months due to signs of prostatic disease. Intact dogs with prostatomegaly and mineralization not diagnosed with neoplasia had paraprostatic cysts (n=3), cystic hyperplasia (n=2), benign prostatic hyperplasia (n=1) or E.coli prostatitis (n=1).
Prostatomegaly with mineralization detected by abdominal radiography or ultrasound is highly indicative of neoplasia in neutered dogs but less reliable in sexually intact dogs.