Advances in Understanding Bovine Cell-Mediated Immunity
ACVIM 2008
James A. Roth, DVM, PhD, DACVM
Ames, IA, USA

References

1.  Asai K, Yamaguchi T, Kuroishi T, Komine Y, Kai K, Komine K, Kumagai K. Differential gene expression of cytokine and cell surface molecules in T cell subpopulation derived from mammary gland secretion of cows. Am J Reprod Immunol. 2003 Dec;50(6):453-62.

2.  Baldwin CL, Sathiyaseelan T, Naiman B, White AM, Brown R, Blumerman S, Rogers A, Black SJ. Activation of bovine peripheral blood gammadelta T cells for cell division and IFN-gamma production. Vet Immunol Immunopathol. 2002 Sep 10;87(3-4):251-9.

3.  Blumerman SL, Herzig CT, Baldwin CL. WC1+ gammadelta T cell memory population is induced by killed bacterial vaccine. Eur J Immunol. 2007 May;37(5):1204-16.

4.  Blumerman SL, Herzig CT, Rogers AN, Telfer JC, Baldwin CL. Differential TCR gene usage between WC1- and WC1+ ruminant gammadelta T cell subpopulations including those responding to bacterial antigen. Immunogenetics. 2006 Aug;58(8):680-92. Epub 2006 Jun 24.

5.  Blumerman SL, Wang F, Herzig CT, Baldwin CL. Molecular cloning of bovine chemokine receptors and expression by WC1+ gammadelta T cells. Dev Comp Immunol. 2007;31(1):87-102. Epub 2006 May 2.

6.  Cassidy JP, Bryson DG, Gutiérrez Cancela MM, Forster F, Pollock JM, Neill SD. Lymphocyte subtypes in experimentally induced early-stage bovine tuberculous lesions. Immune responses in bovine tuberculosis. Tuberculosis (Edinb). 2001;81(1-2):103-7.

7.  Daubenberger CA, Taracha EL, Gaidulis L, Davis WC, McKeever DJ. Bovine gammadelta T-cell responses to the intracellular protozoan parasite Theileria parva. Infect Immun. 1999 May;67(5):2241-9.

8.  Denis M, Wedlock DN, Buddle BM. Ability of T cell subsets and their soluble mediators to modulate the replication of Mycobacterium bovis in bovine macrophages. Cell Immunol. 2004 Nov-Dec;232(1-2):1-8. Epub 2005 Feb 10.

9.  Donovan DC, Reber AJ, Gabbard JD, Aceves-Avila M, Galland KL, Holbert KA, Ely LO, Hurley DJ. Effect of maternal cells transferred with colostrum on cellular responses to pathogen antigens in neonatal calves. Am J Vet Res. 2007 Jul;68(7):778-82.

10. Endsley JJ, Quade MJ, Terhaar B, Roth JA. Bovine viral diarrhea virus type 1- and type 2-specific bovine T lymphocyte-subset responses following modified-live virus vaccination. Vet Ther. 2002 Winter;3(4):364-72.

11. Endsley JJ, M Quade, B Terhaar, JA Roth. BHV-1--Specific CD4+, CD8+, and γδ T cells in calves vaccinated with one dose of a modified live BHV-1 vaccine. Viral Immunol, 2002.15(2):385-393.

12. Endsley JJ, JA Roth, J Ridpath, J Neill. Maternal antibody blocks humoral but not T cell responses to BVDV. Biologicals, 2003. 31:123-125.

13. Endsley JJ, JF Ridpath, JD Neill, MR Sandbulte, JA Roth. Induction of T lymphocytes specific for BVD virus in calves with maternal antibody. Viral Immunol, 2004. 17(1):13-23.

14. Graff JC, Behnke M, Radke J, White M, Jutila MA. A comprehensive SAGE database for the analysis of gammadelta T cells. Int Immunol. 2006 Apr;18(4):613-26. Epub 2006 Feb 28.

15. Hagberg M, Wattrang E, Niskanen R, Tråvén M, Höglund J, Lundén A. Mononuclear cell subsets in bronchoalveolar lavage fluid during Dictyocaulus viviparus infection of calves: a potential role for gamma/delta TCR-expressing cells in airway immune responses? Parasite Immunol. 2005 May;27(5):151-61.

16. Hedges JF, Cockrell D, Jackiw L, Meissner N, Jutila MA. Differential mRNA expression in circulating gammadelta T lymphocyte subsets defines unique tissue-specific functions. J Leukoc Biol. 2003 Feb;73(2):306-14.

17. Hedges JF, Lubick KJ, Jutila MA. Gamma delta T cells respond directly to pathogen-associated molecular patterns. J Immunol. 2005 May 15;174(10):6045-53.

18. Kennedy HE, Welsh MD, Bryson DG, Cassidy JP, Forster FI, Howard CJ, Collins RA, Pollock JM. Modulation of immune responses to Mycobacterium bovis in cattle depleted of WC1(+) gamma delta T cells. Infect Immun. 2002 Mar;70(3):1488-500.

19. Kennedy HE, Welsh MD, Cassidy JP, Bryson DG, Forster F, McNair J, Gangadharan B, Howard CJ, Pollock JM. The role of WC1(+) gamma delta T-cells in the delayed-type hypersensitivity (DTH) skin-test reaction of Mycobacterium bovis-infected cattle. Vet Immunol Immunopathol. 2003 Jun 20;93(3-4):169-76.

20. Koets A, Rutten V, Hoek A, van Mil F, Müller K, Bakker D, Gruys E, van Eden W. Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function. Infect Immun. 2002 Jul;70(7):3856-64.

21. Lahmers KK, Hedges JF, Jutila MA, Deng M, Abrahamsen MS, Brown WC. Comparative gene expression by WC1+ gammadelta and CD4+ alphabeta T lymphocytes, which respond to Anaplasma marginale, demonstrates higher expression of chemokines and other myeloid cell-associated genes by WC1+ gammadelta T cells. J Leukoc Biol. 2006 Oct;80(4):939-52.

22. Lahmers KK, Norimine J, Abrahamsen MS, Palmer GH, Brown WC. The CD4+ T cell immunodominant Anaplasma marginale major surface protein 2 stimulates gammadelta T cell clones that express unique T cell receptors. J Leukoc Biol. 2005 Feb;77(2):199-208. Epub 2004 Nov 2.

23. Liebana E, Marsh S, Gough J, Nunez A, Vordermeier HM, Whelan A, Spencer Y, Clifton-Hardley R, Hewinson G, Johnson L. Distribution and activation of T-lymphocyte subsets in tuberculous bovine lymph-node granulomas. Vet Pathol. 2007 May;44(3):366-72.

24. Lubick K, Jutila MA. LTA recognition by bovine gammadelta T cells involves CD36. J Leukoc Biol. 2006 Jun;79(6):1268-70. Epub 2006 Mar 21.

25. Naiman BM, Alt D, Bolin CA, Zuerner R, Baldwin CL. Protective killed Leptospira borgpetersenii vaccine induces potent Th1 immunity comprising responses by CD4 and gammadelta T lymphocytes. Infect Immun. 2001 Dec;69(12):7550-8.

26. Naiman BM, Blumerman S, Alt D, Bolin CA, Brown R, Zuerner R, Baldwin CL. Evaluation of type 1 immune response in naïve and vaccinated animals following challenge with Leptospira borgpetersenii serovar Hardjo: involvement of WC1(+) gammadelta and CD4 T cells. Infect Immun. 2002 Nov;70(11):6147-57.

27. Platt R, Burdett W, Roth JA. Induction of antigen-specific T-cell subset activation to bovine respiratory disease viruses by a modified-live virus vaccine. Am J Vet Res. 2006 Jul;67(7):1179-84.

28. Platt R, JA Roth, RL Royer, CO Thoen. Monitoring responses by use of 5-color flow cytometry in subsets of peripheral T cells obtained from cattle inoculated with a killed Mycobacterium avium subspecies paratuberculosis vaccine. Am J Vet Res, 2006. 67(12):2050-2058.

29. Platt R, C Coutu, T Meinert, JA Roth. Humoral and T Cell-mediated immune responses to bivalent killed bovine viral diarrhea virus vaccine in beef cattle. Vet Immunol. Immunopathol. 2008. In Press

30. Price SJ, Sopp P, Howard CJ, Hope JC. Workshop cluster 1+ gammadelta T-cell receptor T cells from calves express high levels of interferon-gamma in response to stimulation with interleukin-12 and -18. Immunology. 2007 Jan;120(1):57-65. Epub 2006 Oct 11.

31. Rhodes SG, Hewinson RG, Vordermeier HM. Antigen recognition and immunomodulation by gamma delta T cells in bovine tuberculosis. J Immunol. 2001 May 1;166(9):5604-10.

32. Rogers AN, VanBuren DG, Hedblom E, Tilahun ME, Telfer JC, Baldwin CL. Function of ruminant gammadelta T cells is defined by WC1.1 or WC1.2 isoform expression. Vet Immunol Immunopathol. 2005 Oct 18;108(1-2):211-7.

33. Rogers AN, Vanburen DG, Hedblom EE, Tilahun ME, Telfer JC, Baldwin CL. Gammadelta T cell function varies with the expressed WC1 coreceptor. J Immunol. 2005 Mar 15;174(6):3386-93.

34. Rogers AN, Vanburen DG, Zou B, Lahmers KK, Herzig CT, Brown WC, Telfer JC, Baldwin CL. Characterization of WC1 co-receptors on functionally distinct subpopulations of ruminant gamma delta T cells. Cell Immunol. 2006 Feb;239(2):151-61. Epub 2006 Jul 7.

35. Sandbulte MR, JA Roth. T-cell populations responsive to bovine respiratory syncytial virus in seronegative calves. Vet Immunol Immunopathol, 2002. 84:111-123.

36. Sandbulte MR, Roth JA. Priming of multiple T cell subsets by modified-live and inactivated bovine respiratory syncytial virus vaccines. Vet Immunol Immunopathol. 2003 Oct 15;95(3-4):123-33.

37. Sandbulte MR, JA Roth. Methods for analysis of cell-mediated immunity in domestic animal species. J Am Vet Med Assoc, 2004. 225:522-530.

38. Smyth AJ, Welsh MD, Girvin RM, Pollock JM. In vitro responsiveness of gammadelta T cells from Mycobacterium bovis-infected cattle to mycobacterial antigens: predominant involvement of WC1(+) cells. Infect Immun. 2001 Jan;69(1):89-96.

39. Sopp P, Howard CJ. IFN gamma and IL-4 production by CD4, CD8 and WC1 gamma delta TCR(+) T cells from cattle lymph nodes and blood. Vet Immunol Immunopathol. 2001 Aug 30;81(1-2):85-96.

40. Van Rhijn I, Rutten VP, Charleston B, Smits M, van Eden W, Koets AP. Massive, sustained gammadelta T cell migration from the bovine skin in vivo. J Leukoc Biol. 2007 Apr;81(4):968-73. Epub 2007 Jan 18.

41. Wangoo A, Johnson L, Gough J, Ackbar R, Inglut S, Hicks D, Spencer Y, Hewinson G, Vordermeier M. Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, gammadelta (WC1+) T cells and CD 68+ cells. J Comp Pathol. 2005 Nov;133(4):223-34. Epub 2005 Sep 8.

42. Waters WR, Palmer MV, Pesch BA, Olsen SC, Wannemuehler MJ, Whipple DL. Lymphocyte subset proliferative responses of Mycobacterium bovis-infected cattle to purified protein derivative. Vet Immunol Immunopathol. 2000 Dec 29;77(3-4):257-73.

43. Waters WR, Rahner TE, Palmer MV, Cheng D, Nonnecke BJ, Whipple DL. Expression of L-Selectin (CD62L), CD44, and CD25 on activated bovine T cells. Infect Immun. 2003 Jan;71(1):317-26.

44. Welsh MD, Cunningham RT, Corbett DM, Girvin RM, McNair J, Skuce RA, Bryson DG, Pollock JM Influence of pathological progression on the balance between cellular and humoral immune responses in bovine tuberculosis. Immunology. 2005 Jan;114(1):101-11.

45. Welsh MD, Kennedy HE, Smyth AJ, Girvin RM, Andersen P, Pollock JM. Responses of bovine WC1(+) gammadelta T cells to protein and nonprotein antigens of Mycobacterium bovis. Infect Immun. 2002 Nov;70(11):6114-20.

46. Werling D, Collins RA, Taylor G, Howard CJ Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus. J Leukoc Biol. 2002 Aug;72(2):297-304.

Speaker Information
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James Roth, DVM, PhD, DACVM
Iowa State Univeristy
Ames, IA


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