Advances in Understanding Bovine Native Defense Mechanisms
ACVIM 2008
James A. Roth, DVM, PhD, DACVM
Ames, IA, USA


1.  Ahmed M, Kimura K, Soliman M, Yamaji D, Okamatsu-Ogura Y, Makondo K, Inanami O, Saito M. Effects of leptin and tumor necrosis factor-alpha on degranulation and superoxide production of polymorphonuclear neutrophils from Holstein cows. J Vet Med Sci. 2007 Feb;69(2):125-31.

2.  Ahmed M, Shaban Z, Yamaji D, Okamatsu-Ogura Y, Soliman M, Abd Eldaim M, Ishioka K, Makondo K, Saito M, Kimura K. Induction of proinflammatory cytokines and caspase-1 by leptin in monocyte/macrophages from holstein cows. J Vet Med Sci. 2007 May;69(5):509-14.

3.  Alluwaimi AM. The cytokines of bovine mammary gland: prospects for diagnosis and therapy. Res Vet Sci. 2004 Dec;77(3):211-22.

4.  Bannerman DD, Paape MJ, Hare WR, Hope JC. Characterization of the bovine innate immune response to intramammary infection with Klebsiella pneumoniae J Dairy Sci. 2004 Aug;87(8):2420-32.

5.  Britti D, Peli A, Massimini G, Polci A, Luciani A, Famigli-Bergamini P. Evaluation of TNF-alpha, IL-8 and IL-10 transcriptional activity in milk from healthy dairy cows during lactation period. Vet Res Commun. 2005 Aug;29 Suppl 2:281-4.

6.  Buckham Sporer KR, Burton JL, Earley B, Crowe MA. Transportation stress in young bulls alters expression of neutrophil genes important for the regulation of apoptosis, tissue remodeling, margination, and anti-bacterial function. Vet Immunol Immunopathol. 2007 Jul 15;118(1-2):19-29. Epub 2007 Apr 8.

7.  Burton JL, Madsen SA, Chang LC, Weber PS, Buckham KR, van Dorp R, Hickey MC, Earley B. Gene expression signatures in neutrophils exposed to glucocorticoids: a new paradigm to help explain "neutrophil dysfunction" in parturient dairy cows. Vet Immunol Immunopathol. 2005 May 15;105(3-4):197-219.

8.  Eicher SD, McMunn KA, Hammon HM, Donkin SS. Toll-like receptors 2 and 4, and acute phase cytokine gene expression in dexamethasone and growth hormone treated dairy calves. Vet Immunol Immunopathol. 2004 Apr;98(3-4):115-25.

9.  Endsley JJ, Endsley MA, Estes DM. Bovine natural killer cells acquire cytotoxic/effector activity following activation with IL-12/15 and reduce Mycobacterium bovis BCG in infected macrophages. J Leukoc Biol. 2006 Jan;79(1):71-9. Epub 2005 Nov 7.

10. Hammon DS, Evjen IM, Dhiman TR, Goff JP, Walters JL. Neutrophil function and energy status in Holstein cows with uterine health disorders. Vet Immunol Immunopathol. 2006 Sep 15;113(1-2):21-9. Epub 2006 Jun 5.

11. Howard CJ, Charleston B, Stephens SA, Sopp P, Hope JC. The role of dendritic cells in shaping the immune response. Anim Health Res Rev. 2004 Dec;5(2):191-5.

12. Kampen AH, Olsen I, Tollersrud T, Storset AK, Lund A. Lymphocyte subpopulations and neutrophil function in calves during the first 6 months of life. Vet Immunol Immunopathol. 2006 Sep 15;113(1-2):53-63.

13. Kauf AC, Rosenbusch RF, Paape MJ, Bannerman DD. Innate immune response to intramammary Mycoplasma bovis infection. J Dairy Sci. 2007 Jul;90(7):3336-48.

14. Kimura K, Goff JP, Kehrli ME Jr, Reinhardt TA. Decreased neutrophil function as a cause of retained placenta in dairy cattle. J Dairy Sci. 2002 Mar;85(3):544-50.

15. Lamote I, Meyer E, Duchateau L, Burvenich C. Influence of 17beta-estradiol, progesterone, and dexamethasone on diapedesis and viability of bovine blood polymorphonuclear leukocytes. J Dairy Sci. 2004 Oct;87(10):3340-9.

16. Miyazawa K, Aso H, Honda M, Kido T, Minashima T, Kanaya T, Watanabe K, Ohwada S, Rose MT, Yamaguchi T. Identification of bovine dendritic cell phenotype from bovine peripheral blood. Res Vet Sci. 2006 Aug;81(1):40-5. Epub 2005 Oct 25.

17. Mÿller-Doblies D, Arquint A, Schaller P, Heegaard PM, Hilbe M, Albini S, Abril C, Tobler K, Ehrensperger F, Peterhans E, Ackermann M, Metzler A. Innate immune responses of calves during transient infection with a noncytopathic strain of bovine viral diarrhea virus. Clin Diagn Lab Immunol. 2004 Mar;11(2):302-12.

18. Muneta Y, Yoshihara K, Minagawa Y, Nagata R, Yasuyuki M, Yamaguchi T, Takehara K. Bovine IL-18 ELISA: detection of IL-18 in sera of pregnant cow and newborn calf, and in colostrum. J Immunoassay Immunochem. 2005;26(3):203-13.

19. Paape MJ, Bannerman DD, Zhao X, Lee JW. The bovine neutrophil: Structure and function in blood and milk. Vet Res. 2003 Sep-Oct;34(5):597-627.

20. Peli A, Scagliarini A, Britti D, Boari A. Detection of proinflammatory and regulatory cytokines in bovine milk using RT-PCR. Vet Res Commun. 2003 Sep;27 Suppl 1:779-81.

21. Persson Waller K, Colditz IG, Lun S, Ostensson K. Cytokines in mammary lymph and milk during endotoxin-induced bovine mastitis. Res Vet Sci. 2003 Feb;74(1):31-6.

22. Peterhans E, Jungi TW, Schweizer M. BVDV and innate immunity. Biologicals. 2003 Jun;31(2):107-12.

23. Pfaffl MW, Wittmann SL, Meyer HH, Bruckmaier RM. Gene expression of immunologically important factors in blood cells, milk cells, and mammary tissue of cows. J Dairy Sci. 2003 Feb;86(2):538-45.

24. Rinaldi M, Moroni P, Paape MJ, Bannerman DD. Evaluation of assays for the measurement of bovine neutrophil reactive oxygen species. Vet Immunol Immunopathol. 2007 Jan 15;115(1-2):107-25. Epub 2006 Sep 26.

25. Singh J, Murray RD, Mshelia G, Woldehiwet Z. The immune status of the bovine uterus during the peripartum period. Vet J. 2007 Mar 30 [Epub ahead of print].

26. Sporer KR, Xiao L, Tempelman RJ, Burton JL, Earley B, Crowe MA. Transportation stress alters the circulating steroid environment and neutrophil gene expression in beef bulls. Vet Immunol Immunopathol. 2007 Oct 23 [Epub ahead of print]

27. Sugisawa H, Itou T, Saito M, Moritomo T, Miura Y, Sakai T. A low-molecular-weight fraction of bovine colostrum and milk enhances the oxidative burst activity of polymorphonuclear leukocytes. Vet Res Commun. 2003 Sep;27(6):453-61

28. Takahashi H, Odai M, Mitani K, Inumaru S, Arai S, Horino R, Yokomizo Y. Effect of intramammary injection of rboGM-CSF on milk levels of chemiluminescence activity, somatic cell count, and Staphylococcus aureus count in Holstein cows with S. aureus subclinical mastitis. Can J Vet Res. 2004 Jul;68(3):182-7.

29. Tanaka S, Sato M, Onitsuka T, Kamata H, Yokomizo Y. Inflammatory cytokine gene expression in different types of granulomatous lesions during asymptomatic stages of bovine paratuberculosis. Vet Pathol. 2005 Sep;42(5):579-88.

30. Thacker TC, Palmer MV, Waters WR. Associations between cytokine gene expression and pathology in Mycobacterium bovis infected cattle. Vet Immunol Immunopathol. 2007 Oct 15;119(3-4):204-13. Epub 2007 Jun 2.

31. Werling D, Collins RA, Taylor G, Howard CJ. Cytokine responses of bovine dendritic cells and T cells following exposure to live or inactivated bovine respiratory syncytial virus. J Leukoc Biol. 2002 Aug;72(2):297-304.

32. Werling D, Hope JC, Howard CJ, Jungi TW. Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists. Immunology. 2004 Jan;111(1):41-52.

33. Werling D, Koss M, Howard CJ, Taylor G, Langhans W, Hope JC. Role of bovine chemokines produced by dendritic cells in respiratory syncytial virus-induced T cell proliferation. Vet Immunol Immunopathol. 2002 Sep 10;87(3-4):225-33.

34. Yamanaka H, Hagiwara K, Kirisawa R, Iwai H. Proinflammatory cytokines in bovine colostrum potentiate the mitogenic response of peripheral blood mononuclear cells from newborn calves through IL-2 and CD25 expression. Microbiol Immunol. 2003;47(6):461-8.

35. Yamanaka H, Hagiwara K, Kirisawa R, Iwai H. Transient detection of proinflammatory cytokines in sera of colostrum-fed newborn calves. J Vet Med Sci. 2003 Jul;65(7):813-6.

36. Yamane D, Kato K, Tohya Y, Akashi H. The relationship between the viral RNA level and upregulation of innate immunity in spleen of cattle persistently infected with bovine viral diarrhea virus. Vet Microbiol. 2007 Nov 17 [Epub ahead of print].

Speaker Information
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James Roth, DVM, PhD, DACVM
Iowa State Univeristy
Ames, IA

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