Sodium Carboxymethylcellulose and Hyaluronic Acid on Prevention of Intraabdominal Adhesions in Rats
Many materials for the prevention of intraabdominal adhesions are developed.
This study was carried out to compare the efficacy of sodium carboxymethylcellulose (SCMC) and hyaluronic acid (HA) on intraabdominal adhesions.
The SCMC and HA solution were respectively administered to abdominal cavity in two groups with saline treatment group as a control. The abdominal cavity of each rat (n=11) was coated with 2 ml of the allocated solution just after the abdomen was opened, and it was coated with each solution of 1 ml before abrasion were caused on the cecum, ascending colon and transverse colon. Then, additional 1 ml solution was injected before the abdomen was closed.
On day 14 after the operation, each regional adhesion evaluated at the score of 0-4. The HA and SCMC group showed significantly lower adhesion scores than control group in all regions (P<0.05). The adhesion scores of ascending colon, transverse colon and no abrasion region of the viscera revealed little difference between HA group and SCMC group (P<0.05), but it was found to be lower in HA group than SCMC. The adhesion score of the cecum was significantly lower in HA group than SCMC (P<0.05).
These findings suggest that HA solution is more effective on prevention of adhesions than SCMC solution.