Regeneration of the Adrenal Cortex after Surgical Biopsy of the Adrenal Gland in the Dog
World Small Animal Veterinary Association World Congress Proceedings, 2007
Davoud Kazemi1; Ghasem Babadoost2; Darioush Mohajeree3
1Department of Veterinary Surgery, Faculty of Veterinary Medicine, Islamic Azad University-Tabriz Branch, Tabriz, Iran; 2Graduate of the Faculty of Veterinary Medicine, Islamic Azad University-Tabriz Branch, Tabriz, Iran; 3Department of Veterinary Pathology, Faculty of Veterinary Medicine, Islamic Azad University-Tabriz Branch, Tabriz, Iran

Background and Aims

Biopsy or partial resection of the adrenal glands in the dog is infrequently performed and therefore little information is available about the healing of these glands after surgery. The aim of this study was to determine whether the canine adrenal gland heals by regeneration or fibrous tissue deposition following surgical biopsy.


Ten clinically healthy adult mixed breed dogs (5 male and 5 female) with mean body weight of 21.795±6.174 kg were used in the study. The left adrenal gland in each animal was exposed by paracostal celiotomy and a tissue sample of at least 0.25×0.25 cm was collected from the cranial pole of each gland. The remaining adrenal capsule was sutured over the cut margin using 4/0 nylon suture material and the celiotomy incision closed routinely. The animals were euthanized 30 days after the biopsy and sections of the left adrenal glands examined under light microscope for evidence of tissue repair in the biopsy area.


Tissue repair was evident in the cut margins of all glands macroscopically as invaginated areas of cortical zone with creamy yellow colour with fibrosis and increased thickness of the capsule. Microscopically, wound healing was observed as regeneration of the adrenal cortex leading to the formation of newly formed area of zona glomerulosa at the biopsy site and differentiation of zona glomerulosa cells into zona fasciculata cells in the deeper parenchymal areas. The differentiating cells had active and hyperchromatic nuclei.


To the author's knowledge, this is the first study to demonstrate that the canine adrenal cortex has regenerative capacity which could prove invaluable in adrenal surgery.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

Davoud Kazemi
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Islamic Azad University-Tabriz Bra
East Azarbaijan, Iran

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.


777 W. Covell Blvd., Davis, CA 95616


  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357