Isolation and Genetic Screening of TFAP2B gene in Dogs with Patent Ductus Arteriosus
World Small Animal Veterinary Association World Congress Proceedings, 2007
ChangbaigHyun1; Shin-Aeh Lee2; Seung-Gon Lee2; Changbaig Hyun2
2School of Veterinary Medicine, 1Kangwon National University
Kangwon-do, Republic of Korea

Background

The TFAP2B gene encodes a member of the AP-2 family of transcription factors and is a responsible for a familial patent ductus arteriosus (PDA) in human. PDA is the most common congenital heart defect in dogs.

Aim

To isolate canine TFAP2B gene for genetic screening in dogs with PDA.

Material and Methods

We isolated the full length coding exon of TFAP2B gene. The canine TFAP2B gene was screened for identifying novel mutation(s) in dogs with PDA.

Results

To date, no mutation causing coding sequencing alteration has been identified in dogs with PDA. However, we are still collecting samples and screening this gene in various breeds of dogs with PDA.

Conclusion

Canine TFAP2B gene has been isolated and is now available for genetic screening for genetic aetiology in dogs with congenital heart defects, especially PDA.

Speaker Information
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Changbaig Hyun
Kangwon National University
Kangwon-do, Republic of Korea


MAIN : Abstracts - Poster : Isolation & Genetic Screening
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