Pyruvate Kinase Deficiency and AB Blood Types in Australian Abyssinian and Somali Cats
World Small Animal Veterinary Association World Congress Proceedings, 2007
V.R. Barrs; J.A. Beatty; B. Wilson; A.E. Lingard; C.T.T. Chan; L. Tran; A. Seng; U. Giger

Background

Hereditary pyruvate kinase (PK) deficiency and AB blood type incompatibility can result in severe haemolysis.

Aims

To determine the frequency of the mutant PK allele and AB blood types in Australian Abyssinian and Somali cats.

Methods

A complete blood count, reticulocyte count, DNA PK mutation testing and blood typing were performed in all cats recruited from the Australasian breed association.

Results

Sixty cats (36 Abyssinians, 24 Somalis) were tested comprising 31 females (29 entire, 2 neutered) and 29 males (21 entire, 8 neutered). For the mutant PK allele, 3 female Somalis (2 entire multiparous and 1 neutered, 2-3 years old) were homozygous (5%), 17 cats were heterozygous (28.3%) and 40 cats tested negative (66.7%). Of affected cats, 2 had regenerative anaemias and all had reticulocytosis (range 64-390 x 109/L; p< 0.001 compared to normal or carrier cats) and were alive 1.5 years after testing. The only consistent historical sign was lethargy. Pedigree analysis revealed common ancestry. The mutant allele frequency was 0.29 in the Somali group, 0.13 in the Abyssinian group and 0.19 overall. All cats had blood type A.

Conclusion

The mutant PK allele frequency is high and DNA screening of these breeds is indicated worldwide especially when there is reticulocytosis, even in the absence of anaemia or clinical signs. The risk of haemolytic anaemia from AB blood incompatibility in this population is low.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

Vanessa Barrs
Valentine Charlton Cat Centre, Faculty of Veterinary Science, The University of Sydney
NSW, Australia


MAIN : Abstracts - Oral : Pyruvate Kinase Deficiency
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.

CONTACT US

777 W. Covell Blvd., Davis, CA 95616

vingram@vin.com

PHONE

  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357
SAID=27