Department of Veterinary Medicine, National Taiwan University, Roosevelt road, Taipei, Taiwan
The aim of this study was to evaluate the effect of benazepril on the systemic blood pressure in dogs with heart failure. Twenty client-owned dogs presented with clinical signs related to heart failure were investigated. The diagnosis of heat failure of these 20 dogs was based on clinical signs, chest radiographs, electrocardiography, and echocardiography. The systemic blood pressure was measured using by Doppler ultrasonographic sphygmomanometry. For each dog, the systemic blood pressure was measured before and after benazepril administration regularly at 1 to 2 week intervals for 16 weeks. During these 16 weeks (benazepril 0.1 mg/Kg, q 12 hours), improvements of clinical signs, including cough, tachypnea, appetite, and exercise endurance, were evaluated by both the clients and veterinarians regularly. Clinical improvement was clearly recognized toward the end of 16 week-course of benazepril administration in all 20 dogs. The mean systemic blood pressure before benazepril administered was 142.1 ± 22.6 mmHg. The mean blood pressure after 16 week-course of benazepril was 139.6 ± ± 17.1 mmHg. No significant difference of the mean blood pressure before and after benazepril (P=0.54) was observed. No substantial changes of systemic blood pressure were found to be related to benazepril doses (P = 0.36). The result of this investigation indicated that benazepril (0.1 mg/Kg, q 12 hours) did not affect the systemic blood pressure in dogs with heart failure.