Hemodynamic Variables in Dogs Anesthetized With Etomidate Intravenous Infusion
Department of Veterinary Clinics and Surgery, Faculdade de Ciências Agrárias e Veterinárias-FCAV/Unesp. Rod. Professor Paulo Donato Castelane, s/n. CEP: 14884-900, Jaboticabal, SP. Brazil
The aim of this work was to evaluate the effects of etomidate intravenous infusion on intracranial pressure and cardiac parameters in dogs. Ten healthy adults dogs, male and females ones, whose weight ranged from 4.8 to 11.7 kg were used. General anesthesia was induced using intravenously etomidate at a dose of 5 mg/kg. The animal received oxygen at 100% by endotracheal tube in an anesthetic circuit for mechanical ventilation with rate and amplitude to maintain the end tidal carbon dioxide in 35 mmHg. After the induction the animals received intravenous infusion of etomidate in a rate of 0.5 mg/kg/min during 10 minutes. This rate was reduced to 0.2 mg/kg/min and maintained until the end of the experiment. Heart rate (HR), systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressure, central venous pressure (CVP), pulmonary artery pressure (PAP), cardiac output (CO), stroke volume (SV), systemic vascular resistance (SVR) and body temperature (BT) were measured. The measurements were taken 30 minutes after the positioning of the intracranial catheter (M1). Serial measurements were carried out at 20 minutes intervals after M1 up to 60 minutes (M2, M3 and M4). Data were evaluated by analysis of variance for repeated measures (ANOVA), followed by Tukey test (p<0.05). BT decreased during the experiment. Etomidate infusion did not promote alterations in the other variables. The results allowed concluding that etomidate intravenous infusion maintain stable the hemodynamic variables in dogs.