New Antidemodecosis Remedy
World Small Animal Veterinary Association World Congress Proceedings, 2005
Kakha Nadiradze
President, Zoo-Veterinary Service Center

We, Georgian call our country ''Sakartvelo''--Land of the Georgian. The country is situated in the south of the Caucasus Region, and occupies 69.700 sq. m. Georgia borders with Russia in the North, Azerbaijan in the south-east, Armenia in the south, Turkey in the Southwest, and the Black sea in the west. Georgian is distinguished by its complex and varied relief. The North is dominated by the mountains of the Great Caucasus Range (Cavcasioni), while southern Georgia is traversed by the South Georgian Plateau. From the shore of the Black Sea in the west to the Alazani Valley in the east run the inter-mountain lowlands of Georgia. The mountain range Likhi divides the country into two parts differing in climate: the Eastern Georgia and the Western Georgia. The highest peak is Shkhara (5068 m), the lowest place (-1.5 m) is environs of the lake Palliastomi in the Colchis Lowland. Almost all climate and soil zones and types existing in the world, from the humid subtropical to the eternal snow and icy peaks are represented in the comparatively small territory of Georgia. Georgia's location between moderately humid Mediterranean and dry continental Arab-Caspian areas influences its climate. A humid sub-tropical climate dominates in Western Georgia, while in Eastern Georgia there is a transition from sub-tropical to temperature climate. The average temperature for the coldest month, January, varies from +3°C to 2°. The average temperature in August, the warmest month, is +23°C + 26°C. In seaside areas of Western Georgia mean annual precipitations vary from 1.000 to 2.800 mm (in the mountains), to 300-600 mm in Eastern Georgia. Nature is generously rich in Georgia. One can hardly find many places in the whole world that may hold such diverse landscapes within such a small area--from humid subtropics to perennial snows and glaciers of high mountains.

One of the most actual problems of the contemporary veterinary medicine is demodicosis of small animals. Demodicosis is spread over the world, most frequently in dogs and is related with great economic losses. Except of dogs the sensibility in relation to Demodicosis characterizes also many kinds of animals, including domestic, and also humans.

Working out of effective measures against demodicosis has a great significance. The difficulty of treatment is related to localization and the feeding feature of the mite.

Demodectic mite penetrates deeply in the hair root and thus reside.

Today one of the widespread antimodectic drugs is Ivomec (Ivermectin)--the enzymatic product of fundus Streptomyces avermitilis. Ivomec is effective for treatment of demodicosis, though this drug was not intended for this purpose. The aim of our investigation, is the revealing of antidemodectic action of the drug. Trials of disease. The trial was performed in two experimental and one control groups. The drug has been administered subcutaneously with weekly intervals, (3-5 procedures). Clinical attention was paid to the drug effects, the liver functions, blood system, general condition and other values. Liver and kidney functions were investigated by laboratory studies. Specifically, there was investigated hepatoproductive function of the liver and the hepatotoxicity of the drug. Laboratory studies has confirmed that the dog causes transient depression of hepatoproductive function in less degree them other ones. The hepatotoxicity of the drug we could not reveal. Laboratory studies of kidney functions revealed transient mild depression specifically increase of serum creatine and blood urea. Concluding finally the usage of the drug in appropriate dosage and schedule of administration is accompanied by reversible mild effects.

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Kakha Nadiradze
President, Zoo-Veterinary Service Center

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