Use of Neostigmine in Massive Ivermectin Toxicity in Cats
World Small Animal Veterinary Association World Congress Proceedings, 2005
Ghulam Muhammad, DVM, PhD; Abdul Jabbar, DVM, MSc (Hons.); M.Z. Khan, DVM, PhD; M. Saqib, DVM, MSc (Hons.)
Faculty of Veterinary Science, University of Agriculture
Faisalabad, Pakistan

Over-the-counter availability of drugs in developing countries poses the risk of their abuse and overdosing in animals by the owners themselves. This report describes ivermectin toxicosis and its treatment with neostigmine methylsulfate in two kittens and an adult cat that had been massively overdosed by their owners. Of the two 4-wk-old 300g kittens, one (case-2) injected with 1.5ml (15mg; corresponding to 250 times that of general therapeutic dose) ivermectin by the owner became comatose, started salivation and died after two and a half hours. The other kitten (case-1) treated with about 0.75ml (7.5mg; corresponding to 125 times that of general therapeutic dose) of ivermectin by the same owner developed ataxia and salivation after two hours but went into coma next morning and was presented for treatment. Clinical examination of this kitten revealed mydriasis, coma, slight fever (102.4 °F), tachypnea (respiration rate 48/min) and severe tachycardia. This kitten treated twice at half hourly interval with a mixture of neostigmine methylsulfate (25µg) and 5% dextrose (20ml) IV showed a transient improvement but died twelve hours later. A 2-y-old, 4.5kg male cat (case-3) was similarly treated with 1.5ml (15mg; corresponding to 16.6 times that of general therapeutic dose) of ivermectin by its owner. The clinical examination of this cat revealed a slight salivation, lacrimation, mydriasis, protrusion of third eye-lid, tachypnea (42 breaths/min), tachycardia (128 beats /min) and ataxia. The patient was treated with a mixture of neostigmine methylsulfate (150µg) and 5% dextrose (100ml) IV, followed by intravenous administration of 200ml of Heartmann's solution. The treatment was repeated after 6hrs. Follow up treatment over next two days comprised daily IV administration of neostigmine and dextrose. The patient completely recovered after 5day of initiation of treatment.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

Ghulam Muhammad, DVM, PhD


MAIN : Abstracts, Poster : Neostigmine in Massive Ivermectin Toxicity
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.

CONTACT US

777 W. Covell Blvd., Davis, CA 95616

vingram@vin.com

PHONE

  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357
SAID=27