Effect of Low-Level Laser Therapy on Osteoarthropathy in Rabbit
World Small Animal Veterinary Association World Congress Proceedings, 2004
Cho HJ1, Kim YS1, Oh DM1, Sim KM1, Kang SS1, Choi SH2 and Bae CS1
1College of Veterinary Medicine, Chonnam National University, Republic of Korea; 2College of Veterinary Medicine, Chungbuk National University, Republic of Korea


The aim of this study was to determine whether low-level laser therapy (LLLT) aided the recovery of damaged articular cartilage in joints with artificially induced osteoarthropathy (OA).

Materials and Methods

Osteoarthropathy was induced chemically by injecting 0.5 ml of 4% hydrogen peroxide (H2O2) into the articular space of both knees in rabbits, twice a week for 4 weeks. The induction of OA and the effect of LLLT were evaluated by biochemical, radiologic and histopathologic analysis.


Superoxide dismutase (SOD) activity increased about 40% in the OA group, as compared to the controls. Although SOD activity in the OA group was not significantly different from the 2-week groups, it was significantly different from the 4-week control and treatment groups. There was also a significant difference between the 4-week control and treatment groups. Simple radiographs and three-dimensional computed tomographs (3D CT) did not show detectable arthropathy in the OA group, and showed no special findings in the 2-week groups. By contrast, distinct erosions were seen in the distal articular cartilage of the femur, with irregularity of the articular surface, in the 4-week control group, while the erosions were reduced and arthropathy improved slightly in the 4-week treatment group. Grossly, erosions formed on the articular surface in the OA group. In comparison, severe erosions damaged the articular cartilage in the 4-week control group, but not in the 2-week control and treatment groups. Regeneration of articular cartilage was seen in gross observations in the 4-week treatment group. Histopathologically, there was slight irregularity of articular surface and necrosis in the OA group, and serious cartilage damage, despite slight chondrocyte regeneration, in the 4-week control group. By contrast, the 4-week treatment group showed chondrocyte replacement, with close to normal articular cartilage on the articular surface sometimes.


These results suggest that LLLT was effective in the treatment of chemically induced OA.


1.  Abatangelo et al (1989), Clin Orthop, 241, 278-285.

2.  Bae et al (2002), Korean J Vet Res, 42, 153-162.

3.  Oegema et al (1997), Microsc Res Tech, 37(4), 324-332.

Speaker Information
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C S Bae
College of Veterinary Medicine, Chonnam National University
Republic of Korea

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