The Role of Autogenous Non-Vascularized Free Greater Omentum in Experimental Bone Healing in Rabbit
World Small Animal Veterinary Association World Congress Proceedings, 2004
A. Derakhshanfar, M.M.Oloumi, M. Tayebi
Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran

Finding a simple, applied and inexpensive method to increase the rate of bone healing can reduce the convalescent period and its side effects. In this study the role of autogenous greater omentum as a non-vascularized free flap has been assessed in an experimental model of tibial defect.

The study was carried out on 10 white New Zealand rabbits in the same condition. Following anesthesia and surgical preparation, a 2 mm hole was drilled in medial cortex of both tibial diaphysis. A small piece of greater omental fat (about 3×3 mm), was obtained through a small midline incision and put over the left tibial hole. All the incisions were closed routinely. The animals were sacrificed 14 days after operation and histopathologic sections were taken from the bones at the site of the holes (H&E staining).

In treatment group (left tibia), the fat was changed to a dense soft tissue. Histopathologically, the soft tissue consisted of granulation tissue with severe angiogenesis and hemorrhage. Bone sections in treatment group showed mild hemorrhage with thickened granulation tissue, whereas, in control group hemorrhage and early granulation tissue could be seen.

Since angiogenesis is considered essential to fracture healing, and there are some growth factors in greater omentum (e.g. vascular endothelial growth factor, angiogenic peptide basic fibroblast growth factor, transforming growth factor-beta 1), which can release from it and induce angiogenesis at the site of fracture, it can be concluded that autogenous greater omentum can be considered as an effective and accessible substance to augment fracture healing.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

A. Derakhshanfar
Faculty of Veterinary Medicine
Shahid Bahonar University of Kerman
Kerman, Iran

MAIN : Abstracts : Experimental Bone Healing in Rabbit
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.


777 W. Covell Blvd., Davis, CA 95616


  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357