A Histopathologic Study on the Side Effects of the Diclofenac Sodium in Rabbits
World Small Animal Veterinary Association World Congress Proceedings, 2004
M. Pourjafar*, A. Derakhshanfar**
* Faculty of Veterinary Medicine, Shahrekord University, Shahrekord-Iran; ** Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman-Iran

Diclofenac sodium is one of the non-steroidal anti-inflammatory drugs, which used in human and veterinary medicine frequently. This drug is effective in treatment of diseases such as, musculoskeletal derangement, rheumatoid arthritis and gout. However, the application of this drug has been limited due to its side effects include, gastrointestinal, renal and hepatic lesions. In this research 24 female 2 months old rabbit of about 1.6 kg weight were divided to 4 equal groups randomly and injected intramuscularly, once a day in a period of 10 days. In group 1 as control only normal saline was injected. Groups 2, 3 and 4 received the drug 1,1.5 and 2 mg/kg respectively. At the end of experiment, the animals were euthanized and macroscopic and microscopic lesions in stomach, kidney and liver were studied. Macroscopic inspections revealed congestion of the liver and kidney in group 3 and 4. However, histopathologic examinations showed not any lesion in group 1, lymphocytic hepatitis, fatty change of the liver and renal fibrosis in group 2, hepatic necrosis, lymphocytic hepatitis, glomerular atrophy, interstitial nephritis, renal fibrosis, thickening of the bowman s capsule, renal pelvis fibrosis and gastric edema in group 3 and glomerular atrophy, renal medullary and pelvis fibrosis, acute tubular necrosis, interstitial nephritis, giant cell formation, hepatitis and gastric edema in group 4. Inhibition of prostaglandins is the most important cause of these side effects. The present results have emphasized on usage the drug with precautionary measures.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

M. Pourjafar
Faculty of Veterinary Medicine, Shahrekord University

MAIN : Abstracts : Side Effects of the Diclofenac
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.


777 W. Covell Blvd., Davis, CA 95616



  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357