Cardiopulmonary and Acid Base Effect of Desflurane and Sevoflurane in Spontaneously Breathing Cats
World Small Animal Veterinary Association World Congress Proceedings, 2004
N. Nunes, A. P. de Souza, P. N. H. Guerrero, C. T. Nishimori, D. P. de Paula, P. S. P. dos Santos, M. L. de Rezende
Department of Veterinary Clinics and Surgery, Faculdade de Ciências Agrárias e Veterinárias-FCAV/Unesp. Rod. Professor Paulo Donato Castelane, Brazil.

The cardiopulmonary and acid-base effects of desflurane and sevoflurane anesthesia in cats breathing spontaneously were compared.

To this 12 adult healthy, male and female cats were used. They were separated into two groups of 6 cats each (GD and GS). Anesthesia was induced with propofol (8 + 2.3 mg/kg IV) and maintained with desflurane (GD) or sevoflurane (GS), both at 1.3 MAC. Heart (HR) and respiratory (RR) rates; systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressures; end tidal CO2 (ETCO2), arterial blood pH (pH), arterial partial pressure of O2 (PaO2) and CO2 (PaCO2); base deficit (BD), arterial oxygen saturation (SaO2), bicarbonate ion concentration (HCO3) and total CO2 (TCO2) were measured. The measurements were taken before the induction of the anesthesia (T0) and at 20 minutes (T20), 40 minutes (T40) and 60 minutes (T60) of volatile anesthesia. Data were evaluated by analysis of variance (ANOVA), followed by the Tukey test (p<0.05).

Regarding the arterial pressures (SAP, DAP and MAP), no differences between groups were observed and the HR and RR of both groups were significantly reduced from the baseline with the administration of the volatile anesthetics, but remained stable during anesthesia. ETCO2 significantly increased in both groups after the beginning of anesthesia (T20) and remained high thereafter. The blood gas analyses showed a significant reduction of the pH baseline values with the administration of the inhalant anesthetics. The PaO2 was significantly different between groups throughout the experimental period. GD had the lower values (T20 to T60). However the PaO2 values remained constant within the groups during anesthesia. The PaCO2 increased in both groups with anesthesia (T20) and remained constant until the end of the experimental period. BD was significantly higher in GD than in GS. HCO3 values were lower with desflurane than with sevoflurane. The same happened to TCO2. Both anesthetics caused acidemia and hypercapnia.

It was possible to conclude that despite maintaining the cardiovascular parameters stable, either desflurane and sevoflurane cause acute respiratory acidosis in spontaneously breathing cats.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

N. Nunes
Department of Veterinary Clinics and Surgery
Faculdade de Ciências Agrárias e Veterinárias

MAIN : Abstracts : Spontaneously Breathing Cats
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.


777 W. Covell Blvd., Davis, CA 95616


  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357