The purpose of this study was to compare conventional metal pins with xenograft pins made from bovine cortical bone. The long bones of a young bull were collected from a slaughterhouse, cut into longitudinal sections, and shaped similar to conventional metal pins. They were then processed through oxidizing, degreasing, hydration, drying and sterilization by ethylene oxide. The prepared bovine bone pins were used for fixation of tibial fractures in five dogs (group 1) and conventional metal pins were used in another five dogs (group 2). The dogs were monitored and evaluated clinically daily and radiographically every 30 days for 180 days. Radiographic assessment was performed based on the scores given to various radiographic signs and a total score calculated for each radiograph. Clinically on the 60th postoperative day 80% of animals in the first group and 40% of the cases of the second group were able to put weight on the treated leg. At 90 days post operation 60% of the animals in the first group and 40% in the second group were able to walk on the treated leg. On the 120th day all the dogs could stand and walk normally on the treated leg. Comparison of the total radiographic score showed significant differences (P<0.05) between the two groups. All of the xenograft bone pins were absorbed on 180th postoperative day while showing a complete healing at the fracture site in 40% of the dogs in the first group. Periosteal and endosteal reaction, callus formation and absorption of excess callus was evident during the healing process and remodeling of the bone was in progress. It was concluded that xenograft bone pins made from bovine bone can serve as a means of internal fixation for fracture treatment and its gradual absorption increases osteogenesis and osteoinduction, and therefore hastening healing time without need for removal.