Duration of efficacy and effect of implant location in adult queens treated with a 9.4 mg deslorelin subcutaneous implant.

Theriogenology. January 2025;231(0):190 - 196.

A Baldan¹, M Pereira², V Pedrotti³, S Ferro⁴, D Gelli⁵, C Milani⁶, Mollo A⁷, C Fontaine⁸, G.M. De Benedictis⁹, C Stelletta¹⁰, S Romagnoli¹¹

¹ Private Practitioner, Padova, Italy.; ² Department of Animal Medicine, Production and Health of the University of Padova, Italy. Electronic address: mariacarlos.pereira@phd.unipd.it.; ³ Private Practitioner, Padova, Italy.; ⁴ Department of Comparative Biomedicine and Food Science of the University of Padova, Italy.; ⁵ Department of Animal Medicine, Production and Health of the University of Padova, Italy.; ⁶ Department of Animal Medicine, Production and Health of the University of Padova, Italy.; ⁷ Department of Animal Medicine, Production and Health of the University of Padova, Italy.; ⁸ Companion Animal Medical Department, Virbac, Carros, France.; ⁹ Department of Animal Medicine, Production and Health of the University of Padova, Italy.; ¹⁰ Department of Animal Medicine, Production and Health of the University of Padova, Italy.; ¹¹ Department of Animal Medicine, Production and Health of the University of Padova, Italy.

Abstract

Deslorelin is a GnRH-agonist used off-label for contraception in female cats. Little is known about duration and safety of the 9.4 mg subcutaneous implant in the queen as well as its efficacy when placed periumbilically. Fourteen female cats were administered the 9.4 mg deslorelin implant (during interestrus or anestrus) either in interscapular (N = 8) or periumbilical (N = 6) sites, following general and reproductive examination, vaginal cytology, hematology, biochemistry and progesterone assay to ensure health status. All above procedures (except for progesterone assay) were repeated weekly during the first month, then every 2 months until 6 months and then every 6 months until treated cats regained full reproductive function. No side effects were observed in any treated queen. Post implantation estrus occurred in 40 % of the subjects. A significant increase in body weight was observed during treatment (12/14 queens gained weight), particularly at the end of the study. At the end of the study some queens mated, conceived and kittened, proving reversibility of the treatment. The average duration of action of the 9.4 mg deslorelin implant was 790 ± 155 days (range 525-1140 days) with no significant difference in duration or efficacy depending on implantation sites. The 9.4 mg deslorelin implant causes pharmacological sterilization for about 2 years in female cats, is fully reversible and caused no clinically relevant side effects when administered at both interscapular and periumbilical sites.

Keywords

9.4 mg deslorelin; Periumbilical; Reproduction control; queen;

Article Tools:

Medline

Email to me

Archives Highlights:

Owner satisfaction and prognosis for return to work after pancarpal arthrodesis in working dogs in the United Kingdom: a retrospective study (2011-2020).
50% (5/10) owners stated their dog could perform normal duties; 4/10 (40%) could perform most duties with some allowances. 80% (8/10) owners rated the level of post-operative lameness as unaffected with a normal gait. 90% (9/10) owners were either very satisfied or satisfied with the outcome of the procedure, and 90% owners stated the financial investment was worthwhile.

Factors Associated with Medication Noncompliance in Dogs in New Zealand.
Medication noncompliance was recorded for 47% (71/151) of owners. Increasing dog age was associated with better owner compliance. Forty-seven percent (71/151) of owners reported that "nobody" showed them how to administer the medication. One-third of dog owners (47/151) reported challenges in medicating their pets. The most common reason cited by clients reporting challenges was a resistant pet.

Transmucosal administration of pentobarbital and phenytoin solution induces euthanasia in bearded dragons (Pogona vitticeps).
An initial dose of euthanasia solution containing pentobarbital and phenytoin sodium was administered transmucosally in conscious lizards (100 mg/kg pentobarbital dose), followed by a second dose 20 minutes later (400 mg/kg pentobarbital dose). The median time to death was 300 minutes (range, 300 to 360 minutes), median time to respiratory arrest was 30 minutes (range, 30 to 50 minutes), and median time to loss of deep pain response was 30 minutes (range, 20 to 50 minutes). Signs consistent with oral irritation occurred in 4 of 6 (66.7%) lizards, including 2 lizards that exhibited whole-body spasms after euthanasia solution administration.

The Prevalence and Diagnosis of Feline Heartworm Infection
Visualization of supposed worm structures on echocardiography, in conjunction with a positive antigen test result, is as close to a definitive antemortem confirmation of adult heartworm infection as can be achieved.

Feline acute patient physiologic and laboratory evaluation scores and other prognostic factors in cats with first-time diabetic ketoacidosis.
Median BG was significantly higher in non-survivors (431 mg/dL) compared with survivors (343 mg/dL) and BG predicted mortality. For every 1 mg/dL increase in BG, the odds of death increased by 1.004.