ABSTRACT OF THE WEEK

Journal of veterinary internal medicine/ American College of Veterinary Internal Medicine
Volume 36 | Issue 3 (May 2022)

Myoclonus in older Cavalier King Charles Spaniels.

J Vet Intern Med. May 2022;36(3):1032-1038.

Carina Rotter¹, Danielle Whittaker², Clare Rusbridge³

¹ Orthopedics and Neurology, Fitzpatrick Referrals Ltd, Surrey, United Kingdom.; ² Orthopedics and Neurology, Fitzpatrick Referrals Ltd, Surrey, United Kingdom.; ³ Orthopedics and Neurology, Fitzpatrick Referrals Ltd, Surrey, United Kingdom.

Abstract

BACKGROUND:Myoclonus is observed in older Cavalier King Charles Spaniels (CKCS) but a full description is lacking.

OBJECTIVES:The presence, age of onset, characteristics and treatment of myoclonic episodes were retrospectively evaluated in a cohort of CKCS which presented to 1 board-certified neurologist. Clinical data, imaging studies, presence of seizures and their management, as well as other comorbidities were noted.

ANIMALS:Thirty-nine CKCS that were presented to 2 institutions between 2001 and 2018 with signs consistent with myoclonus. Clinical examination, blood sampling, advanced diagnostic imaging, cerebrospinal fluid analysis, and record keeping of other comorbidities was performed.

METHODS:This is a retrospective case series, describing the presence of myoclonus in CKCS.

RESULTS:Clinical signs reported were spontaneous in onset, lasted a few seconds and consisted of rapid blinking with head nodding and variable extension down the thoracic limbs. Myoclonus occasionally led to stumbling of the thoracic limbs or collapse. Mean age of onset was 8.38 years (SD ±1.96). Thirteen of 39 dogs with myoclonus had paroxysmal events, such as generalized seizures (9/13).

CONCLUSIONS AND CLINICAL IMPORTANCE:Myoclonus occurs in middle-aged to older CKCS and seems to be another epiphenomena of this breed. A link to epilepsy might be present.

Keywords

involuntary movement; levetiracetam; myoclonic epilepsy; nonrhythmic muscle twitching; primary progressive myoclonus of aging;

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