Effect of Clostridium butyricum on Gastrointestinal Infections.
Biomedicines. February 2022;10(2):.
Tadashi Ariyoshi1, Mao Hagihara2, Motomichi Takahashi3, Hiroshige Mikamo4 1 Department of Clinical Infectious Diseases, Aichi Medical University, Nagakute 480-1195, Aichi, Japan.; 2 Department of Clinical Infectious Diseases, Aichi Medical University, Nagakute 480-1195, Aichi, Japan.; 3 Department of Clinical Infectious Diseases, Aichi Medical University, Nagakute 480-1195, Aichi, Japan.; 4 Department of Clinical Infectious Diseases, Aichi Medical University, Nagakute 480-1195, Aichi, Japan.
Abstract
Clostridium butyricum is a human commensal bacterium with beneficial effects including butyrate production, spore formation, increasing levels of beneficial bacteria, and inhibition of pathogenic bacteria. Owing to its preventive and ameliorative effects on gastrointestinal infections, C. butyricum MIYAIRI 588 (CBM 588) has been used as a probiotic in clinical and veterinary medicine for decades. This review summarizes the effects of C. butyricum, including CBM 588, on bacterial gastrointestinal infections. Further, the characteristics of the causative bacteria, examples of clinical and veterinary use, and mechanisms exploited in basic research are presented. C. butyricum is widely effective against Clostoridioides difficile, the causative pathogen of nosocomial infections; Helicobacter pylori, the causative pathogen of gastric cancer; and antibiotic-resistant Escherichia coli. Accordingly, its mechanism is gradually being elucidated. As C. butyricum is effective against gastrointestinal infections caused by antibiotics-induced dysbiosis, it can inhibit the transmission of antibiotic-resistant genes and maintain homeostasis of the gut microbiome. Altogether, C. butyricum is expected to be one of the antimicrobial-resistance (AMR) countermeasures for the One-health approach.
Keywords

Clostridioides difficile;
Clostridium butyricum;
Helicobacter pylori;
gastrointestinal infection;
gut dysbiosis;
|
 |
Article Tools:
Archives Highlights:
Trust in veterinarians and association with vaccine information sources and vaccination status among dog and cat owners.
62.9% of dog and 61.2% of cat owners were classified as trusting their veterinarians. On average, dog owners consulted 2.50 sources about vaccine information; cat owners consulted 2.27 sources. Veterinarians were the most common primary sources of information for 85.4% of dog owners with high levels of trust, but only 62.6% of dog owners with lower levels. This was the case for 83.8% and 56.3% of cat owners.
|
Investigating the Reasons behind Companion Animal Relinquishment: A Systematic Content Analysis of Shelter Records for Cats and Dogs, 2018-2023.
The most frequent reasons cited were Behavior Issues (28%), Housing/Moving (18%), Unable to Care (16%), Too Many Pets (10%), Financial (6%), and Owner Allergies (5%). The most common behavioral reasons reported were Aggression (32% of behavioral surrenders), Social Conflict (28%), and Soiling (13%).
|
Prevalence of elbow dysplasia in 13 dog breeds in France: a retrospective radiographic study (2002-2022).
The overall prevalence of ED was 11.4%, ranging from 1.1% in the Czechoslovakian Wolfdog to 32.2% in the Dogue de Bordeaux. The Dogue de Bordeaux, Rottweiler, Bernese Mountain Dog, and Cane Corso breeds were most commonly affected by ED. The prevalence of ED was significantly higher in male dogs than in female dogs (17.5% vs 10.5%). Joint incongruity and fragmented coronoid process were the 2 most common primary ED lesions identified.
|
Effective treatment with afoxolaner (NexGard) of Trixacarus caviae in a pet guinea pig.
The animal was treated with a single oral dose of 2.50 mg/kg afoxolaner, and the lesions, presence/absence of mites, and intensity of pruritus were evaluated periodically until 2 months post-treatment. A week after the medication, the lesions were milder, but pruritus was still present and was attributed to the healing process. Further examinations showed significant improvement with the complete remission of clinical signs and no mites at the microscopic examination after 4 weeks.
|
'Transmission Tracker - Dirofilaria'- a public dashboard to assess in real-time the temperature-bounded transmissibility of canine heartworm across Australia.
'Transmission Tracker - Dirofilaria' processes near real-time temperature records across Australia and allows users to enquire about historical and current weather suitability for canine heartworm transmission at any Australian postcode of their interest. This information allows veterinarians to access when, and for how long, heartworm may be transmitted at a specific location, assess the associated risk of infection, and advise on a patient-dependent dirofilariosis prevention plan for their canine patients and guardians.
|
|