Eward

This presentation will explore several translational efforts in osteosarcoma within the field of Comparative Oncology. The first of these is “Teaching an Old Drug New Tricks.” In this work, the anthelmintic niclosamide is rendered into a new, more bioavailable form through a process called rapid solvent exchange. The new molecule, known as Niclosamide Stearate Prodrug Therapy (NSPT), has gone through in vivo mouse testing and a canine clinical trial. The second theme is “The Mouse-Dog-Human Pipeline.” This is a precision medicine pipeline which studies osteosarcoma across species—in fact, agnostic to species—in an attempt to develop personalized therapies for patients. In the third portion of the talk, we will review a technical study which attempts to use a minimally invasive technique of polymethylmethacrylate osteoplasty for dogs with osteosarcoma being treated with definitive radiation therapy as their means of local control. This technique uses a series of balloon catheters and injection ports to fill the affected portion of the bone with polymethylmethacrylate to prevent one of the dreaded complications of radiation therapy employed to treat osteosarcoma—pathological fractures. These three topics will be viewed through the lenses of successes, failures, and potential next steps.