Meningioangiomatosis in a Dog: A Case Report
WSAVA 2002 Congress
*Carles Morales, Marco Bernardini, Martí Pumarola
*Hospital Clínic Veterinari. Facultat de Veterinària, Campus UAB. Edifici V
Bellaterra, Barcelona, ES
carles.morales@uab.es

HISTORY

A 8-months-old, male, Bernese mountain dog was referred due to previous seizures at six months of age. Clinical signs, results of ancillary tests, and pathological findings are described. The owner reported pain manifestation on head movements. Previously, at four and five months of age, unilateral epistaxis episodes were presented. The dog suffered two generalized seizures (tonic-clonic convulsions with autonomic disturbances) at six months of age. Physical examination was normal. At neurological examination low proprioceptive deficit on right hindlimb and mild cervical pain were detected. Differential diagnostic included inflammatory-infectious disease, congenital abnormality, degenerative disorder and neoplasia. Complete blood count, biochemistry profile, serum bile acids, ammonia levels, TT4/TSH levels, urinalysis, and coagulation profile were normal. Brain magnetic resonance imaging was performed. On T1-weighted images, there was a 5 cm heterogeneous hyperintensity mass, and hydrocephalus (obstructive hydrocephalus). The mass was located between left olfactory bulb, basal nuclei and diencephalon. There was a vasogenic edema in left hemisphere evident on T2-weighted images. After gadolinium intravenous administration there was a slight enhancement of the mass. A presumptive diagnosis of neoplasia or congenital abnormality was made, and the dog was euthanized due to poor prognosis. Histologically the lesion was classified as a meningioangiomatosis.

DISCUSSION

Meningioangiomatosis (MA) is a rare vascular malformation of the central nervous system. It is a benign, focal proliferation of blood vessels and meningothelial cells in brain and leptomeninges. There are only a few reports of MA in dogs. Most of them described the lesion as a congenital vascular malformation, but in some cases neoplastic cells are present. In this dog there was a benign proliferation of spindle-shaped cells arranged in whorls around small blood vessels. Proliferating meningothelial cells infiltrated the brain and formed perivascular cuffs, those cells stained positively for vimentin and S-100. Necrotic areas were observed but any neoplastic cells or mitotic figures were detected.

The pathogenesis is uncertain but probably MA is a vascular malformation that is later accompanied by meningioendothelial cell proliferation without evidence of malignancy. Other hypothesis refers to a congenital hamartomatous malformation. In human medicine there are two populations of patients with MA: symptomatic children and young adults who present headaches or seizures, and asymptomatic individuals. In symptomatic patients, complete or partial resection can be curative.

Speaker Information
(click the speaker's name to view other papers and abstracts submitted by this speaker)

Carles Morales Moliner
Hospital Clínic Veterinari. Facultat de Veterinària
Campus UAB. Edifici V
Bellaterra, Barcelona 08193 ES

Marco Bernardin

Martí Pumarola
Unitat d'Anatomia Patològica. Facultat de Veterinària. UAB


MAIN : : Meningioangiomatosis
Powered By VIN

Friendly Reminder to Our Colleagues: Use of VIN content is limited to personal reference by VIN members. No portion of any VIN content may be copied or distributed without the expressed written permission of VIN.

Clinicians are reminded that you are ultimately responsible for the care of your patients. Any content that concerns treatment of your cases should be deemed recommendations by colleagues for you to consider in your case management decisions. Dosages should be confirmed prior to dispensing medications unfamiliar to you. To better understand the origins and logic behind these policies, and to discuss them with your colleagues, click here.

Images posted by VIN community members and displayed via VIN should not be considered of diagnostic quality and the ultimate interpretation of the images lies with the attending clinician. Suggestions, discussions and interpretation related to posted images are only that -- suggestions and recommendations which may be based upon less than diagnostic quality information.

CONTACT US

777 W. Covell Blvd., Davis, CA 95616

vingram@vin.com

PHONE

  • Toll Free: 800-700-4636
  • From UK: 01-45-222-6154
  • From anywhere: (1)-530-756-4881
  • From Australia: 02-6145-2357
SAID=27