Front Page VSPN Message Boards Chat Library Continual Education Search MyVSPN - Coming Soon Help Frequently Asked Questions Send us Feedback! Go to VIN Industry Partners Go to VetQuest Go to Veterinary Partner Go to Y2Spay
 
Menu bar   Go to the VIN.com Portal
 

ABSTRACT OF THE WEEK

The New England journal of medicine
Volume 374 | Issue 19 (May 2016)

One-Year Outcomes in Caregivers of Critically Ill Patients.

N Engl J Med. May 2016;374(19):1831-41.
Jill I Cameron1, Leslie M Chu2, Andrea Matté3, George Tomlinson4, Linda Chan5, Claire Thomas6, Jan O Friedrich7, Sangeeta Mehta8, François Lamontagne9, Melanie Levasseur10, Niall D Ferguson11, Neill K J Adhikari12, Jill C Rudkowski13, Hilary Meggison14, Yoanna Skrobik15, John Flannery16, Mark Bayley17, Jane Batt18, Claudia dos Santos19, Susan E Abbey20, Adrienne Tan21, Vincent Lo22, Sunita Mathur23, Matteo Parotto24, Denise Morris25, Linda Flockhart26, Eddy Fan27, Christie M Lee28, M Elizabeth Wilcox29, Najib Ayas30, Karen Choong31, Robert Fowler32, Damon C Scales33, Tasnim Sinuff34, Brian H Cuthbertson35, Louise Rose36, Priscila Robles37, Stacey Burns38, Marcelo Cypel39, Lianne Singer40, Cecilia Chaparro41, Chung-Wai Chow42, Shaf Keshavjee43, Laurent Brochard44, Paul Hebert45, Arthur S Slutsky46, John C Marshall47, Deborah Cook48, Margaret S Herridge49, RECOVER Program Investigators (Phase 1: towards RECOVER), Canadian Critical Care Trials Group
1 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 2 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 3 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 4 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 5 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 6 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 7 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 8 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 9 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 10 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 11 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 12 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 13 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 14 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 15 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 16 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 17 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 18 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 19 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 20 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 21 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 22 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 23 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 24 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 25 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 26 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 27 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 28 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 29 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 30 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 31 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 32 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 33 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 34 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 35 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 36 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 37 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 38 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 39 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 40 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 41 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 42 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 43 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 44 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 45 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 46 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 47 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 48 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H; 49 From the Department of Occupational Science and Occupational Therapy (J.I.C., L.C.), Rehabilitation Sciences Institute (J.I.C., S.Mathur, P.R.), Toronto Rehabilitation Institute, University Health Network (J.I.C., J.F., M.B.), Department of Medicine, Toronto General Research Institute, Institute of Medical Science, University Health Network (L.M.C., A.M., G.T., C.T., N.D.F., J.F., M.B., V.L., M.P., D.M., L.F., E.F., M.E.W., P.R., S.B., M.C., L.S., C.C., C.-W.C., S.K., M.S.H.), Interdepartmental Division of Critical Care (J.O.F., S. Mehta, N.D.F., N.K.J.A., J.B., C.S., M.P., C.M.L., R.F., D.C.S., T.S., B.H.C., C.C., C.-W.C., L.B., A.S.S., M.S.H.), Departments of Medicine and Critical Care (J.O.F., J.B., C.S., L.R., L.B., J.C.M.) and Keenan Research Center at the Li Ka Shing Knowledge Institute (L.B., A.S.S., J.C.M.), St. Michael's Hospital, Department of Medicine and Anesthesia, Mount Sinai Hospital (S. Mehta, C.M.L., L.R., L.S.), Department of Critical Care Medicine, Sunnybrook Health Sciences Centre (N.K.J.A., R.F., D.C.S., T.S., B.H.C., L.R.), Interdepartmental Division of Physiatry (J.F., M.B.), Department of Psychiatry, University Health Network (S.E.A., A.T.), and Department of Physical Therapy (S. Mathur), University of Toronto, Toronto, the Departments of General Internal Medicine and Critical Care, St. Joseph's Healthcare (J.C.R.), and the Departments of Pediatrics (K.C.) and Medicine (D.C.), Division of Critical Care and Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (F.L., P.H.) and the School of Rehabilitation and Research Centre on Aging, Health and Social Services Centre (M.L.), University of Sherbrooke, Sherbrooke, QC, the Department of Critical Care, University of Ottawa, Ottawa (H.M.), the Department of Medicine Division of Critical Care, Maisonneuve Rosemont Hospital, University of Montreal, Montreal (Y.S.), and the Department of Medicine, St. Paul's H

Abstract

BACKGROUND:Few resources are available to support caregivers of patients who have survived critical illness; consequently, the caregivers' own health may suffer. We studied caregiver and patient characteristics to determine which characteristics were associated with caregivers' health outcomes during the first year after patient discharge from an intensive care unit (ICU).
METHODS:We prospectively enrolled 280 caregivers of patients who had received 7 or more days of mechanical ventilation in an ICU. Using hospital data and self-administered questionnaires, we collected information on caregiver and patient characteristics, including caregiver depressive symptoms, psychological well-being, health-related quality of life, sense of control over life, and effect of providing care on other activities. Assessments occurred 7 days and 3, 6, and 12 months after ICU discharge.
RESULTS:The caregivers' mean age was 53 years, 70% were women, and 61% were caring for a spouse. A large percentage of caregivers (67% initially and 43% at 1 year) reported high levels of depressive symptoms. Depressive symptoms decreased at least partially with time in 84% of the caregivers but did not in 16%. Variables that were significantly associated with worse mental health outcomes in caregivers were younger age, greater effect of patient care on other activities, less social support, less sense of control over life, and less personal growth. No patient variables were consistently associated with caregiver outcomes over time.
CONCLUSIONS:In this study, most caregivers of critically ill patients reported high levels of depressive symptoms, which commonly persisted up to 1 year and did not decrease in some caregivers. (Funded by the Canadian Institutes of Health Research and others; ClinicalTrials.gov number, NCT00896220.).

Article Tools:
   Medline
   Email to me

Comments:
Comment In Am J Respir Crit Care Med. 2017 Oct 15;196 (8):1068-1070
Comment In J Thorac Dis. 2016 Oct;8(10 ):E1232-E1234
Comment In N Engl J Med. 2016 Sep 8;375(10):1000-2
Comment In N Engl J Med. 2016 Sep 8;375(10):1000
Comment In N Engl J Med. 2016 Sep 8;375(10):1000-2

Grants:
MOP-97809 Canadian Institutes of Health Research

Databanks:
ClinicalTrials.gov/NCT00896220

Archives Highlights:
Feline Stress Management During air Travel: A Multimodal Approach.
While the discussion is focused on air travel specifically, the stress management methods described can be applied to all types of longer distance travel, such as a long road trip or a ferry crossing, as well as a stay in a holiday home.
Acute onset of circling and dull mentation in a 1-year-old male neutered domestic shorthair cat.
CNS cuterebriasis represents a neurologic disease more common in cats than dogs, resulting in presentation during summer months with acute onset and often asymmetric, focal or multifocal, intracranial signs preceded by upper respiratory disease.
Toxocara cati Infection in Cats
The Companion Animal Parasite Council recommends testing kittens for intestinal parasites at least 4 times in the first year of life and twice a year thereafter. Although the prepatent period for T cati infection is 8 weeks, to combat any potential of hookworm infection, treatment for parasitic infection should be initiated at 2 weeks of age and repeated every 2 weeks until regular broad-spectrum parasite control is begun.
Evaluating Communication Training at AVMA COE-Accredited Institutions and the Need to Consider Diversity within Simulated Client Pools.
Participating institutions summarized their communication curricula: 18 (85.71%) used simulated clients (SCs). Over 55% of these did not track SC demographic data or social identities; among institutions that did track, SCs were primarily monolingual English-speaking (77%), non-disabled (94.2%), white (90.4%), non-Hispanic/Latinx (98.6%) women (57%) over age 56 (64%). Sixteen institutions agreed with the statement "I do not feel that our SC pool is adequately diverse."
Reversible control of reproduction in tom cats: medical options for manipulating libido and fertility.
This review focuses on the hormonal drugs for controlling reproduction in male cats currently available to feline practitioners. The reversibility of their effects, which is due to temporary suppression of testosterone secretion and spermatogenesis, makes this option appealing for breeders. The different compounds are described.

Back Print Save Bookmark in my Browser Email this article to me. Top of Page. VSPN AOW : One-Year Outcomes in Care...
Contact Us