ABSTRACT OF THE WEEK

The Veterinary Clinics of North America. Small animal practice
Volume 47 | Issue 1 (January 2017)

Lymphoid Neoplasia: Correlations Between Morphology and Flow Cytometry.

Vet Clin North Am Small Anim Pract. January 2017;47(1):53-70.

Emily D Rout¹, Paul R Avery²

¹ Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 314-4 Diagnostic Medicine Center, 200 West Lake Street, 1644 Campus Delivery, Fort Collins, CO 80523-1644, USA.; ² Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 309 Diagnostic Medicine Center, 200 West Lake Street, 1644 Campus Delivery, Fort Collins, CO 80523-1644, USA. Electronic address: paul.avery@colostate.edu.

Abstract

Cytology is commonly used to diagnose lymphoma and leukemia. Frequently, a diagnosis of lymphoproliferative disease can be obtained via cytology, and some of the common subtypes of canine lymphoma and leukemia can have characteristic cytologic features. Flow cytometry is a critical tool in the objective diagnosis and further characterization of lymphoma and leukemia. Features of the immunophenotype, such as expression of certain cell surface proteins or cell size, can provide important prognostic information. This review describes the cytologic features, flow cytometry immunophenotype, and immunophenotypic prognostic information for 6 major types of canine lymphoma and leukemia.

Article Tools:

Medline

Email to me

Archives Highlights:

Dimethyl sulfoxide favors the emetic efficacy of lycorine in beagle dogs - a novel strategy for the treatment of poisoning.
By emesis response analysis four dimethyl sulfoxide (DMSO)-based active pharmaceutical ingredient (API) formulations were favored. Two of them (lycorine hydrochloride, 15 mg/mL in 70% DMSO, 10% ethanol, and 20% water; and lycorine hydrochloride, 15 mg/mL in 50% DMSO, 50% water) qualified for further drug development. Both formulations ensure a safe pharmacologically induced emesis within about 30 min after injection, suitable for use as an in time decontaminant in acute poisoning of dogs. DMSO-based formulations were well tolerated and offer a novel promising strategy for treatment of poisoning.

Head Trauma Management in Small Animals
This article reviews the pathophysiology of head trauma, patient assessment, diagnostic testing, treatment recommendations, monitoring, and prognosis.

Uroabdomen: Approach and Management
Animals with uroabdomen caused by small defects can potentially be medically managed with intravenous fluid therapy and urinary diversion (with a urinary catheter and/or abdominal drain). In a recent study, 25% of cats with uroabdomen were medically managed, and in another study, 14% of dogs were treated with medical management alone. Otherwise, uroabdomen is generally considered a surgical condition once the patient has been stabilized.

Urinary Tract Trauma in Cats: Stabilisation, Diagnosis and Management.
This review summarises the current knowledge available from a number of original articles and textbook chapters in the literature that cover all aspects of feline urinary tract trauma, and is supported by the authors' own clinical experience.

High-pressure injection of paint into the hand: A small injury with serious consequences.
High-pressure injection injury to the hand is a serious lesion threatening the limb. Several injected materials are involved, and paint is known to have the most serious consequences, with a high amputation rate. Early diagnosis and prompt treatment are two important prognostic factors for a better outcome.