CHOP chemotherapy for the treatment of canine multicentric T-cell lymphoma.

Vet Comp Oncol. March 2011;9(1):38-44.

R B Rebhun¹, M S Kent, S A E B Borrofka, S Frazier, K Skorupski, C O Rodriguez

¹ Department of Surgical and Radiological Sciences, One Shields Avenue, University of California, Davis, CA 95616, USA. rbrebhun@ucdavis.edu

Abstract

Dogs with multicentric T-cell lymphoma are commonly treated with CHOP chemotherapy protocols that include cyclophosphamide, doxorubicin, vincristine and prednisone. The purpose of this study was to evaluate the use of CHOP chemotherapy for dogs with multicentric T-cell lymphoma. Identification of prognostic factors in this specific subset of dogs was of secondary interest. Twenty-three out of 24 dogs responded to CHOP chemotherapy and these dogs remained on the protocol for a median of 146 days. No variable was associated with progression free survival (PFS) including stage, substage, hypercalcemia or radiographic evidence of a cranial mediastinal mass. The median overall survival time (OST) for all dogs was 235 days. Dogs that were thrombocytopenic at presentation experienced a significantly longer OST (323 versus 212 days, P=0.01).

Article Tools:

Medline

Full Text on the Web

Email to me

Archives Highlights:

Computed tomography findings of nasal cryptococcosis in Australia (2008-2020): 12 dogs and 9 cats.
Dogs were more likely to have a nasal mass, whereas cats were more likely to have a nasopharyngeal mass. Cribriform plate lysis was common in dogs, but not observed in cats. Sinonasal osteolysis was a common feature in both species. Mandibular lymph nodes were commonly enlarged in dogs, whereas in cats, the retropharyngeal lymph nodes were more likely enlarged.

Splenic Masses in Dogs: Algorithms for Differentials, Diagnosis, and Definitive Treatment
There is a 63.1% to 70.5% chance a splenic mass is benign if there is no hemoabdomen and a 21.7% to 37.5% chance it is benign if there is hemoabdomen. These numbers replace the two-thirds rule, which said that two-thirds of splenic masses were malignant and two-thirds of malignant masses were HSA, without accounting for hemoabdomen.

Owner survey suggests cats may be undertreated for pain compared to dogs after an elective ovariohysterectomy or orchiectomy.
Analgesics were prescribed for 19 of 162 (12%) pets: 14 of 88 (16%) dogs and 5 of 74 (6.7%) cats. There was no difference in the prescription of analgesics between dogs and cats after ovariohysterectomy or orchiectomy. 15 of 19 owners reported their compliance in administering analgesics at 78.9%. Owners' subjective assessments showed that 24 of 86 (28%) dogs and 12 of 68 (17%) cats appeared painful at home.

Indications for Radiation Therapy in Veterinary Medicine
This article highlights some of the essential elements for clinical decision making in veterinary radiation oncology, with case examples to give general practitioners a better understanding of what types of cases may be appropriate for radiation therapy.

Prevalence of discospondylitis and association with congenital vertebral body malformations in English and French bulldogs.
The prevalence of discospondylitis was 3.4 (1.6-6.7) times higher in French bulldogs and 4.3 (1.7-9.8) times higher in English bulldogs, compared with the overall hospital cohort. One or more vertebral malformations were present in 12 French bulldogs (92.3%), 6 English bulldogs (75.0%), and 1 "other" breed dog (1.1%). Discospondylitis was diagnosed adjacent to congenital vertebral body malformations in 12 (80%) intervertebral discs in French bulldogs and 5 (50%) intervertebral discs in English bulldogs.