ONCO110-0915: Cancer and the Immune System
The lectures for this course will be presented in a predominantly audio format.
Please come prepared to listen.

Enrollment is closed.

Instructor: Amanda Guth, DVM, PhD
Course Open: September 14-October 8, 2015
Real Time Sessions (RTS): Mondays, September 21 and 28, 2015; 9:30-11:30 pm ET (USA)
Course RTS Times in Your Area: World Clock Converter

Practice Sessions: In order to prepare you for a successful experience in your CE course, we request you attend a Practice Session prior to the first Real Time Session. Please arrive promptly at the start time; each Practice Session is up to 1 hour in length. For more information, please visit the CE Practice Area.

*The instructors for this course will be using audio which will require you to have a headset or speakers to listen. If you have any concerns regarding your computer's audio capabilities, please be sure to attend one of the Practice Sessions.

Level and Prerequisites: This intermediate course will be open to veterinarians actively interested in the immune system and its role in preventing cancer.
VIN CE Course: Open to veterinarians. This course is approved by RACE for veterinarians. The Veterinary Information Network (VIN) is RACE Provider #22.

Course Description:
The immune system plays an important role in preventing cancer and attacking malignant cells once a tumor occurs. This course is designed to explain the interplay between tumor cells and the immune system during tumor development, with an emphasis on the key immune cells that play roles in both eliminating the tumor cells as well as assisting in tumor growth, as well as how the tumor tricks the immune system in order to prevent antitumor immunity. Moreover, this course will cover novel cancer immunotherapeutics, both currently available for veterinary use and novel therapies being researched. After this course, participants will have a better understanding of tumor immunity and available immune system-based therapies to better inform their clients and consider alternate cancer therapies.

This course consists of two(2) 2-hour Real Time Sessions, supplemental library materials, interactive message board discussions, and a mandatory end-of-course test. Successful completion (scoring 80% or better) on the end-of-course test is required to earn a certificate of completion for the course.

To learn more about the requirements for earning a CE certificate, please refer to Receiving Your CE Credit and Course Completion Certificate.

*The lecture portion of this course will be an audio presentation, please be prepared to listen.

Upon completion of this course, the participant should be able to

• understand the 3E's (elimination, equilibrium and escape) of tumor development in an immune competent animal.
• learn about the key immune cells that play roles in tumor elimination and tumor progression.
• know what cancer immunotherapies have been tested in veterinary patients and which ones are currently available for use in small animals.
• know what new immunotherapies are being researched and might appear in the veterinary market at some point.

Course Materials: Course materials will be available in the course library prior to each Real Time Session.

Required Textbook: There is no required textbook for this course.
Recommended Textbook(s):

• Withrow SJ, Vail DM, Page R. Withrow and MacEwen's Small Animal Clinical Oncology. 5e. Saunders 2012.
  ISBN-13: 978-1437723625
  Available at the VIN Bookstore: http://bookstore.vin.com/9781437723625
  Remember to login in order to receive your VIN discount.

About the Instructors:
Dr. Guth received her PhD in 2003 from the University of Colorado Health Sciences Center where she studied B cells and autoimmunity at National Jewish Health in Denver, Colorado. She then completed her DVM at Colorado State University in 2007 and worked as a post-doctoral fellow studying lung immunology and innate immunity in cancer. She currently is a Research Scientist at Colorado State University where she studies the role of myeloid cells in cancer and the development of novel immunotherapies for cancer and metastatic disease. She also has an interest in developing novel cancer vaccines and understanding the role of the immune system in combination immunotherapy and chemotherapy or radiation therapy. She teaches classes on tumor immunology, clinical trials and large animal immunology. She co-wrote the Immunotherapy Chapter in Withrow and MacEwen's Small Animal Clinical Oncology 5th edition textbook and the Cancer Immunotherapy chapter in Kirk's Current Veterinary Therapy Volume XV.

Course Outline:
Week 1 (Real Time Session September 21, 2015): Tumor Immunity
Content:

• Evidence for immunosurveillance
• 3 E's of tumor development
• Elimination
• Key antitumor innate immune cells
• Key antitumor adaptive immune cells
  • Equilibrium
  • Escape
• Tumor is a wound that does not heal
  • Angiogenesis
  • Inflammatory cells
• Cells that promote tumor cells
  • Monocytes/macrophages
  • T regulatory cells

Week 2 (Real Time Session September 28, 2015): Immunotherapies
Content:

• Currently available therapies
  • Melanoma Vaccine
  • BCG
  • L-MTP-PE
• Tested therapies
  • Superantigens
  • CpG/CLDC
  • Recombinant cytokine therapy
• Future Immunotherapies
  • Salmonella
  • Tumor vaccines
  • Monoclonal antibody therapy
  • Adoptive cells transfers

CE Credits: 4

Tuition: Member $84 ($76 early bird special if enrolled by September 7, 2015)
Non-Member $157 ($141 early bird special if enrolled by September 7, 2015)

*To ensure participants are ready and prepared for classes, enrollment will close on September 21, 2015 at 5 pm ET (USA) or when the maximum number of participants is reached.
*For more information on how online CE works, see the Participant Resource Center.

To Enroll:
Enrollment is closed.

1. Enrollment qualifications: VIN CE courses are open to VIN member and non-member veterinarians. Veterinarians enrolling in a VSPN CE course must be a VIN member. Veterinary support staff must be a VSPN member to enroll in a VSPN CE or a VIN CE course open to VSPN member enrollment.
2. Each enrollee must be able to receive emails from @vspn.org and @vin.com addresses. Email is our major form of communication with participants; personal emails are highly recommended rather than clinic/hospital email addresses.
3. Each person is individually responsible for his/her own registration. To ensure that all information received is secure and correct, please do not enroll for a course on behalf of another individual.
4. For further assistance call 800-846-0028 ext. 797 or email CEonVIN@vin.com. Please include the course title, your full name, and contact information in your correspondence.

*Note: "This course is approved for 4 continuing education credits in jurisdictions which recognize AAVSB RACE approval; however participants should be aware that some boards have limitations on the number of hours accepted in certain categories and/or restrictions on certain methods of delivery of continuing education." Call VIN CE at 800-846-0028 ext. 797 for further information. (Attendees are encouraged to check with their licensing jurisdiction(s) for information regarding recognition by their board).

Course withdrawal and refund policy: A complete refund of the paid course price will be issued when your withdrawal request is received prior to the listed start date of the course. If you wish to withdraw after the start date please contact the VIN office 800-846-0028 ext. 797 to discuss eligibility for a pro-rated refund.
* Note: To ensure rapid handling of your request for withdrawal, we recommend that you call the VIN office at 800-846-0028 ext. 797.

*For more information on VIN's upcoming CE courses, check the VIN Course Catalog.

Katherine James, DVM, PhD, DACVIM (SAIM)
VIN Education Coordinator

VIN CE Services: CEonVIN@vin.com
800-846-0028 or 530-756-4881; ext. 797
or direct line to VIN/VSPN from the United Kingdom: 01 45 222 6154
or direct line to VIN/VSPN from Australia: 02 6145 2357

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